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Thromb Haemost 1962; 08(03): 442-454
DOI: 10.1055/s-0038-1655442
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Is there a Hemostatic Effect of Peanuts in Hemophilioid Disorders?[*]

Pieter Brakman   **
1   The James F. Mitchell Foundation, Institute for Medical Research, Washington Clinic, Washington 15, D.C., USA, and the Biological Institute, Carlsberg Foundation, Copenhagen, Denmark
,
Knud-Erik Sjølin   ***
1   The James F. Mitchell Foundation, Institute for Medical Research, Washington Clinic, Washington 15, D.C., USA, and the Biological Institute, Carlsberg Foundation, Copenhagen, Denmark
,
Tage Astrup   ****
1   The James F. Mitchell Foundation, Institute for Medical Research, Washington Clinic, Washington 15, D.C., USA, and the Biological Institute, Carlsberg Foundation, Copenhagen, Denmark
› Author Affiliations
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Publication History

Publication Date:
14 May 2019 (online)

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Summary

1. Data on the effect of defatted peanuts in hemophilioid patients (deficient in Factor VIII or Factor IX) are presented.

2. Oral administration of peanuts is regularly followed by a decrease in spontaneous fibrinolytic activity of the blood.

3. A clinical effect of peanuts is limited and seems to be present only in mild disorders and in periods of mild relapse.

4. The data supports the concept that the peanut effect is indirect and is caused by an antiprotease delaying fibrinolysis.

* This investigation was supported by the Josiah Macy Jr. Foundation, New York, and by the U. S. Public Health Service, National Heart Institute (Grant HE-05020).


** Research Associate, Member, James F. Mitchell Foundation.


*** Lecturer in pathological Anatomy, University of Copenhagen, Denmark.


**** Director of Research, Chief, James F. Mitchell Foundation.


 

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