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DOI: 10.1055/s-0038-1655483
Chemical Structure and Fibrinolysis Induction
In Vitro Studies with 126 Synthetic Compounds[*] Supported by grants-in-aid from the American Heart Association and the Belle Bonfils Memorial Blood Bank Denver.Publication History
Publication Date:
21 June 2018 (online)
Summary
126 synthetic compounds were tested with the preformed human plasma standard clot for their fibrinolysis-inducing capacity. A variety of compounds were discovered which induce marked fibrinolytic activity in human plasma. There are definite relationships between the structure of the compounds used and the activity in the plasma. The fibrinolytic activity developed in the plasma was demonstrated with fibrinolytic and with proteolytic tests as well as with the standard clot procedure. The details of these findings and their possible significance are discussed.
* Part of the results reported in this paper has been presented in a scientific exhibit entitled “Fibrinolytic Activity Induced by Synthetic Compounds in Vitro: Studies with Human Plasma” at the 8th Congress of the European Society of Haematology, Vienna, 1961.
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References
- 1 Kaulla K. N. von, Smith R. L. Plasma clot dissolution by urea derivatives. Nature 1961; 190: 449
- 2 Kaulla K. N. von, Smith R. L. Urea derivatives as fibrinolysis promoting agents Proc. Soc. exp. Biol. and Med. (N. Y.) 1961; 106: 530
- 3 Kaulla K. N. von. On the mechanism of thrombolysis. Thrombolytic activity and related phenomena. Friedrich-Karl Schattauer-Verlag; Stuttgart: 1961: 171
- 4 Kaulla K. N. von. Fibrinolysis induction in vitro by aromatic derivatives. Arch. Biochem. biophys 1962; 96: 4
- 5 Licht W, Wiener L. D. Hydrotropic solvents for benzoic acid. Indian. Eng. Chem 1950; 42: 1538
- 6 Kaulla K. N. von, Smith R. L. in preparation
- 7 Kaulla K. N. von. The standard clot. Thromb. Diath. haem 1961; 5: 489
- 8 Spiro K. Über die Beeinflussung der Eiweißkoagulation durch stickstoffhaltige Substanzen. 2. phys. Chem 1900; 30: 182
- 9 Neuberg C. Hydrotropische Erscheinungen. Biochem. Z 1916; 76: 107
- 10 Krasnec L. Knasko: Prispevok k závislosti hydrotropie od chemikej konštitúcie. Chemicke Zvesti 1954; 8: 178
- 11 Booth H. S, Everson H. E. Hydrotropic solubilities. Ind. Eng. Chem 1949; 41: 2627
- 12 Durand R. Recherches sur l'hydrotropie. Etude de la solubilité du benzène dans les solutions aqueuses de quelques sels d'acides gras. C. R. Acad. Sci. (Paris) 223: 898 1946;
- 13 Andersen D. L, Freeman A. J. A new family of amphoteric surfactants: Fatty acid amino derivatives. J. Soc. Cosmetics Chemists 1957; 8: 277