Studies on the Pathogenesis of the Generalized Shwartzman Reaction

F Rodríguez-Erdmann

doi:10.1055/s-0038-1655558

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00035024.xml

Share / Bookmark

Facebook Linkedin Weibo

Download PDF

Thromb Haemost 1964; 12(02): 452-461
DOI: 10.1055/s-0038-1655558

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Studies on the Pathogenesis of the Generalized Shwartzman Reaction

I. Alterations in the Coagulation System During the Generalized Shwartzman Reaction of the Pregnant Rabbit

F Rodríguez-Erdmann^*

Further Information

Publication History

Publication Date:
27 June 2018 (online)

Also available at

Abstract
Full Text
References

Buy Article Permissions and Reprints

Summary

The generalized Shwartzman reaction (gSr) was produced in pregnant rabbits by means of a single intravenous injection of E.-coli endotoxin. The animals developed a profound and a haemorrhagic diathesis. The haemorrhagic condition is thought to be the result of an acute consumption of the plasma-factors of the coagulation system. The pathogenesis of the gSr is discussed in the light of literature dealing with this phenomenon.

^* Present address: Dept. of Haematology. Tufts-New England Medical Center, Boston, 11, Mass. 02111, USA.

References
1 Apitz K. Die Wirkung bakterieller Kulturfiltrate nach Umstimmung des gesamten Endothels beim Kaninchen. Virchows Arch. path. Anat. 293: 1-33 1934;

Crossref PubMed Search in Google Scholar
2 Apitz K. A study of the generalized Shwartzman phenomenon. J. Immunol. 29: 255-266 1935;

Crossref PubMed Search in Google Scholar
3 Belnap W. D, O’Donnell J. J. Epidemic gastroenteritis due to escherichia coli O-111. A review of the literature, with the epidemiology, bacteriology and clinical findings of a great outbreak. J. Pediat. 47: 178-193 1955;

Crossref PubMed Search in Google Scholar
4 Bohle A. Vergleichende pathologisch-anatomische Befunde bei schweren Blutgerinnungs-störungen in Gynäkologie und Chirurgie und ihre Beziehung zum morphologischen Bild des generalisierten Shwartzman-Phänomens. In: Physiologie und Pathologie der Blutgerinnung in der Gestationsperiode. Internationales Symposion, Heidelberg 1956. Runge H, und Hartert I. Ed. F. K. Schattauer-Verlag; Stuttgart: 1957: 51-61.

Search in Google Scholar
5 Bohle A. Beitrag zum Sanarelli-Shwartzman-Phänomen während der Schwangerschaft. Vergleichende Untersuchungen an mütterlichen und kindlichen Organen. Verh. dtsch. pathol. Ges. 44: 355-359 1960;

PubMed Search in Google Scholar
6 Bohle A, Krecke H. J. Über das Sanarelli-Shwartzman-Phänomen (sog. generalisiertes Shwartzman-Phänomen) des Menschen. Klin. Wschr. 37: 803-814 1959;

Crossref PubMed Search in Google Scholar
7 Chedid L, Boyer F, Parant M. Etude de l’action abortive des endotoxines injectées a la souris gravide normale, castrée ou hypophysectomisée. Ann. Inst. Pasteur 102: 77-84 1962;

PubMed Search in Google Scholar
8 Cooper A. B, McKay D. Effect of Steroidhormons on the response to bacterial endotoxin. Fed. Proc. 19: 246 1960;

PubMed Search in Google Scholar
9 Engels A, Maurer W, Niklas A. Über das Verhalten von Thorium in graviden und nicht graviden Ratten. Ein Beitrag zur Anwendung der Isotopen in der Medizin. Z. ges. exp. Med. 115: 525-533 1950;

Crossref PubMed Search in Google Scholar
10 Feissly P, Lüdin H. Microscopie par contrastes de phases (III: Applications a l’hématologie). Rev. hémat. 4: 481-501 1949;

PubMed Search in Google Scholar
11 Galton M. Generalized Shwartzman reaction in the pregnant hamster. Science 139: 923-924 1963;

Crossref PubMed Search in Google Scholar
12 Good R. A, Thomas L. Inhibition by heparin of the local and generalized Shwartzman reactions. J. Lab. clin. Med. 40: 804-805 1952;

PubMed Search in Google Scholar
13 Good R. A, Thomas L. Studies on the generalized Shwartzman reaction. In: Prevention of the local and generalized Shwartzman reactions with heparin. J. exp. Med. 97: 871-888 1953;

Crossref PubMed Search in Google Scholar
14 Hartert PL. Blutgerinnungsstudien mit der Thrombelastographie, einem neuen Untersuchungsverfahren. Klin. Wschr. 26: 577-583 1948;

Crossref PubMed Search in Google Scholar
15 Kaley G, Demopoulus H, Zweifach B. W. Occlusive vascular lesions by bacterial endotoxin in the kidneys of pregnant rats. Proc. Soc. exp. Biol. (N.Y.) 109: 456-459 1962;

Crossref PubMed Search in Google Scholar
16 Kleinmaier H. Personal communication, Heidelberg 1960.

PubMed
17 Kleinmaier H, Georgen K, Bäsch H. G, Krecke H. J, Bohle A. Untersuchung zur Frage der Gerinnungsstörung beim Sanarelli-Shwartzman-Phänomen (sog. generalisierten Shwartzman -Phänomen) des Kaninchens. Z. ges. exp. Med. 132: 275-294 1959;

Crossref PubMed Search in Google Scholar
18 Koller F, Loeliger A, Duckert F. Experiments on a new clotting factor (factor VII). Acta haemat. 6: 1-18 1951;

Crossref PubMed Search in Google Scholar
19 Bäsch H. G, Krecke H. J, Rodríguez-Erdmann F, Sessner H. H, Schütterle G. Verbrauchs-koagulopathien (Pathogenese und Therapie). Folia haemat. (n.F.) 6: 325-330 1961;

PubMed Search in Google Scholar
20 Linqqvist B, Erlanson P, Brun A. A case of renal cortical necrosis probably caused by a human equivalent of the Shwartzman reaction. Acta med. scand. 173: 561-567 1963;

PubMed Search in Google Scholar
21 Masland W. S, Barrows L. J. A case of generalized Shwartzman phenomenon in the human. Arch. Neurol. 7: 64-73 1962;

Crossref PubMed Search in Google Scholar
22 McKay D. G, Jewett F. J, Reid D. E. Endotoxin shock and the generalized Shwartzman reaction in pregnancy. Amer. J. Obstet. Gynec. 78: 546-566 1959;

Crossref PubMed Search in Google Scholar
23 McKay D. G, Merril S. J, Weiner A. E, Hertig A. T, Reid D. E. The pathologic anatomy of eclampsia, bilateral cortical necrosis, pituitary necrosis and other fatal complications of pregnancy and its possible relationship to the generalized Shwartzman phenomenon. Amer. J. Obstet. Gynec. 66: 507-539 1953;

Crossref PubMed Search in Google Scholar
24 McKay D. G, Wong T. G. Studies of the generalized Shwartzman reaction produced by diet. J. exp. Med. 115: 1117-1125 1962;

Crossref PubMed Search in Google Scholar
25 McKay D. G, Wong T, Galton M. Effect of pregnancy on the disseminated thrombosis caused by bacterial endotoxin Fed. Proc. 19: 246 1960;

PubMed Search in Google Scholar
26 McKell W. M, Helseth H. K, Brunson J. C. Influence of endotoxin on the placental-fetal barrier. Fed. Proc. 19: 246 1960;

PubMed Search in Google Scholar
27 Panetta I. La terapia anticoagulante nelle tossieme gravidiche. Contributo clinico e sperimentale. Riv. ital. Ginec. 36: 38-84 1953;

PubMed Search in Google Scholar
28 Pechet L, Alexander B. Increased clotting factors in pregnancy. New England J. Med. 265: 1093-1097 1961;

Crossref PubMed Search in Google Scholar
29 Penick G. D, Roberts H. R, Webster W. P, Brinkhous K. M. Hemorrhagic states secondary to intravascular clotting. An experimental study of their evolution and prevention. Arch. Pathol. 06: 708-714 1958;

PubMed Search in Google Scholar
30 Pfau P, Lasch H. G, Günther O. Sanarelli-Shwartzman-Phänomen bei febrilen Fehlgeburten und schweren Schock-und Blutungszuständen in der Gynäkologie. Gynaecol. 150: 17-33 1960;

PubMed Search in Google Scholar
31 Reid D. E, Weiner A. E, Roby C. G. Intravascular clotting and afibrinogenemia, the preventive factors in the syndrome of amniotic fluid embolism. Amer. J. Obst. Gyn. 66: 465-474 1953;

PubMed Search in Google Scholar
32 Rieder R. F, Thomas L. Studies on the mechanisms involved in the production of abortion by endotoxin. J. Immunol. 84: 189-193 1960;

PubMed Search in Google Scholar
33 Rodríguez-Erdmann F. Über eine einfache Methode zur wiederholten Blutgewinnung beim Kaninchen. Pflügers Arch. ges. Physiol. 269: 306-307 1959;

Crossref PubMed Search in Google Scholar
34 Rodríguez-Erdmann F. Studies on the pathogenesis of the generalized Shwartzman reaction. III: Trigger mechanism for the activation of the prothrombin molecule. Thrombos. Diathes. haemorrh. (Stuttg.) 12: 411 1964;

PubMed Search in Google Scholar
35 Rodríguez-Erdmann F. Blood clotting as related to the pathogenesis of the Sanarelli-Shwartz-man phenomenon. A review. In preparation

PubMed
36 Rodríguez-Erdmann F, Dameshek W. Pathogenesis of bilateral cortical necrosis of the kidneys. I: Its production be means of exogenous fibrin. In press

PubMed
37 Rodríguez-Erdmann F, Krecke H. J, Lasch H. G, Bohle A. Über die morphologischen und gerinnungsanalytischen Veränderungen nach Liquoid. Ein Beitrag zur Pathogenese des Sanarelli-Shwartzman-Phänomens. Z. ges. exp. Med. 134: 109-130 1960;

Crossref PubMed Search in Google Scholar
38 Rodríguez-Erdmann F, Lasch H. G. Qualitative und quantitative Störungen der Thrombozyten nach Injektion hochmolekularer Poiymerer. (Ein Beitrag zum Sanarelli-Shwartzman -Phänomen). Thrombos. Diathes. haemorrh. (Stuttg.) 5: 518-530 1960;

PubMed Search in Google Scholar
39 Rodríguez-Erdmann F, Lasch H. G. Die Rolle von intravasal auftretendem Thrombin beim Sanarelli-Shwartzman-Phänomen. Proc. 8th Congress Europ. Soc. Haematol. Vienna 1961, Nr 468. Karger; Basel: 1962

Search in Google Scholar
40 Rodríguez-Erdmann H, Lasch G. Fenómeno de Sanarelli-Shwartzman durante la gestación. Proc. IX Congress Internat. Soc. Haematol. Mexico-City, 1962. p. 85-90

PubMed
41 Rothenberg J, Margaretten W, McKay D. G. Blockade of the reticuloendothelial system (RES) by dietary lipids. Fed. Proc. 22: 671 1963;

PubMed Search in Google Scholar
42 Stork H. Über hämorrhagische Phänomene in der Dermatologie. Dermatologica (Basel) 102: 197-252 1947;

PubMed Search in Google Scholar
43 Takeda Y, Tsuchiya I. Studies on the pathological changes caused by the injection of the Shwartzman filtrate and the endotoxin into pregnant rabbits. Jap. J. exp. Med. 23: 9-16 1953;

PubMed Search in Google Scholar
44 Thomas L. The generalized Shwartzman reaction in rabbits infected with group A hemolytic streptococci. In: Rheumatic fever, a symposium. University of Minnesota Press.; Minneapolis: 1952: 232-246.

Search in Google Scholar
45 Volhard F. Experimentelle und kritische Studien zur Pathogenese der Eklampsie. Mschr. Geburtsh. Gynäk. 5: 411-437 1897;

PubMed Search in Google Scholar
46 Wong T. G. A study on the generalized Shwartzman reaction in pregnant rats induced by bacterial endotoxin. Amer. J. Gynec. Obst. 84: 786-797 1962;

PubMed Search in Google Scholar
47 Zahl P. A, Byerknes C. Induction of decidua-placental hemorrhage in mice by endotoxins of certain Gram-negative bacteria. Proc. Soc. exp. Biol. 54: 329-332 1943;

Crossref PubMed Search in Google Scholar

Subscribe to RSS

Share / Bookmark

Studies on the Pathogenesis of the Generalized Shwartzman Reaction

Publication History

Summary

References