Clot-Dissolving Action of Echis Colorata Venom in Dogs

Summary

Echis colorata venom inoculation into dogs enhances dissolution of pulmonary emboli produced by insertion of autologous clots into the inferior caval vein.

^* This investigation was supported by a research grant (AI-03171) from the U.S. National Institutes of Health, Bethesda.

• References

• 1 Rechnic J, Trachtenberg P, Gasper J, Moroz Gh, de Vries A. Afibrinogenemia and thrombocytopenia in guinea pigs following injection of Echis colorata venom. Blood 20: 735 1962;
• 2 Djaldetti M, Joshua H, Ressier P.L, Rosen M, Gutglas H, de Vries A. Coagulation disturbance in the dog following Echis colorata venom inoculation. Hémostase 4: 323 1965;
• 3 Moaw B, Moroz Ch, de Vries A. Activation of the fibrinolytic system of the guinea pig following inoculation of Echis colorata venom. Toxicon 1: 109 1963;
• 4 Djaldetti M, Sandbank U. A simple method for marking a clot obtained in vitro. Stain technology 1966. (In press.)
• 5 Dacie J. Y, Lewis S. M. Practical Haematology. Third Ed.. J. & Churchill; 1963
• 6 Quick A. J. The hemorrhagic diseases and the physiology of hemostasis. 1 vol. C. C. Thomas Springfield, Illinois: 1942
• 7 Ratnoff O. D, Menzie C. A new method for the determination of fibrinogen in small samples of plasma. J. Lab. clin. Med 37: 316 1951;
• 8 Wintrobe M. M. Clinical Hematology. Fifth ed.. Lea & Febiger; Philadelphia: 1963
• 9 Laki K, Lorand L. On the solubility of fibrin clots. Science 108: 280 1948;
• 10 vonK aulla K. N. Chemistry of thrombolysis: human fibrinolytic enzymes. 1 vol. Charles C. Thomas; Springfield, Illinois: 1963
• 11 Wessler S, Freiman D. G, Ballon J. D, Katz J. H, Wolff R, Wolf E. Experimental pulmonary embolism with serum-induced thrombi. Amer. J. Path 38: 89 1961;
• 12 Browse N. L, James D. C. O. Streptokinase and pulmonary embolism. Lancet II: 1039 1964;
• 13 Kowarzyk H, Kotschy M. Clot formation and fibrinolysis. Congress of Purkynie Czecoslovak. Med. Soc. Prague, 1962
• 14 Joshua H, Djaldetti M, Ozcan E, Bessler H, Rosen M, de Vries A. Mechanism of thrombocytopenia in the dog and the guinea pig following Echis colorata venom inoculation. Hémostase IV: 333 1965;
• 15 Gitter S, Levi G, Kochwa S, de Vries A, Rechnic J, Casper J. Studies on the venom of Echis colorata. Amer. J. trop. Med 9: 391 1960;