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Thromb Haemost 1964; 12(01): 331-337
DOI: 10.1055/s-0038-1655617
Originalarbeiten – Original Articles – Travaux Originaux
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Abnormal Plasma Clots in Hemophilia

Richard E. Bettigole   *
1   Department of Medicine, University of Oklahoma School of Medicine, Oklahoma City, Oklahoma
,
James W. Hampton
1   Department of Medicine, University of Oklahoma School of Medicine, Oklahoma City, Oklahoma
,
Robert M. Bird
1   Department of Medicine, University of Oklahoma School of Medicine, Oklahoma City, Oklahoma
› Author AffiliationsSupported in part by Research Grant HE 07489, National Heart Institute and Graduate Training Grant T 1 AM 5107, National Institute of Arthritis and Metabolic Diseases, U.S. Public Health Service.
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Publication Date:
27 June 2018 (online)

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Summary and Conclusions

A technique is described for the examination of thin plasma clots with the electron microscope, by which the clots of nine patients with classical hemophilia and five normal controls were studied. The hemophiliacs’ plasma clots were strikingly different from normal, with relatively straight, wide fibrin strands. This difference appeared to be due to their long clotting times. It is proposed that this abnormal end-product of fibrin polymerization in hemophilia, perhaps together with the decreased platelet clumping which also was observed, may be a cause of the functional inadequacy of blood clots in hemophilia.

Presented in part in abstract, Clinical Research 11: 190, 1963 and clinical Research 11: 293, 1963.

* Dr. Bettigole’s present address is: Memorial Sloan-Kettering Cancer Center, 444 East 68th Street, New York 21, New York.


 

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