The Effect of Sulphydryl and Enzyme Inhibitors on Platelet Aggregation in Vitro

M. J. G Harrison; P. R Emmons; J. R. A Mitchell

doi:10.1055/s-0038-1655632

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1966; 16(01/02): 122-133
DOI: 10.1055/s-0038-1655632

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

The Effect of Sulphydryl and Enzyme Inhibitors on Platelet Aggregation in Vitro

Authors

M. J. G Harrison

¹ Department of the Regius Professor of Medicine, Radcliffe Infirmary, Oxford
P. R Emmons

¹ Department of the Regius Professor of Medicine, Radcliffe Infirmary, Oxford
J. R. A Mitchell

¹ Department of the Regius Professor of Medicine, Radcliffe Infirmary, Oxford

Abstract

Summary

The glycolytic enzyme poisons potassium cyanide, sodium fluoride, and monofluoroacetate do not inhibit platelet clumping. The sulphydryl inhibitors, n-ethyl maleimide and p-hydroxymercuribenzoate, inhibit platelet aggregation produced by ADP, ATP, nor-adrenaline, 5HT, thrombin and connective tissue extract. This inhibitory activity is counteracted by 1-cysteine. These results suggest that platelet thiol groups are involved in the platelet adhesion occurring during aggregation.

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Referenzen

References
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