Hemorrhagic Syndrome in Dogs Induced by Intravenous Thrombin

A Girolami; E. E Cliffton; D Agostino

doi:10.1055/s-0038-1655641

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1966; 16(01/02): 243-256
DOI: 10.1055/s-0038-1655641

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Hemorrhagic Syndrome in Dogs Induced by Intravenous Thrombin

A Girolami^*

¹ Clotting Mechanisms Section, Sloan-Kettering Institute for Cancer Research and Cornell University Medical College, New York, New York

,

E. E Cliffton^**

¹ Clotting Mechanisms Section, Sloan-Kettering Institute for Cancer Research and Cornell University Medical College, New York, New York

,

D Agostino^***

¹ Clotting Mechanisms Section, Sloan-Kettering Institute for Cancer Research and Cornell University Medical College, New York, New York

› Author Affiliations

Abstract

Summary

The intravenous administration of thrombin (70 N. I. H. u/kg) caused in the dog a decrease in platelets, factor V, factor VIII and fibrinogen, a prolongation of glass and silicone clotting times, prothrombin and partial thromboplastin times, decreased prothrombin consumption and defective thromboplastin generation. This resulted in a generalized bleeding syndrome. Increased fibrinolysis occurred after an initial phase of inhibition of fibrinolysis. It is suggested that this hemorrhagic syndrome is similar to some conditions observed clinically.

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References

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