Deficiencies and Inhibitors of Thromboplastic Activity

G. F Grannis; L. A Kazal

doi:10.1055/s-0038-1655646

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1966; 16(03/04): 574-585
DOI: 10.1055/s-0038-1655646

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Deficiencies and Inhibitors of Thromboplastic Activity

Authors

G. F Grannis^*

¹Cardeza Foundation for Hematological Research, Jefferson Medical College, Philadelphia, Pennsylvania
L. A Kazal

¹Cardeza Foundation for Hematological Research, Jefferson Medical College, Philadelphia, Pennsylvania

Abstract

Summary

The effects of hereditary deficiencies of thromboplastic proteins (hemophilia A and B) on the time course of thrombin appearance and disappearance in plasma (the thrombin activity curve, TAC) were compared with the effects of a naturally occurring gamma-globulin inhibitor of thromboplastic activity and with an anti-thromboplastic activity derived from cephalin (phosphatidylserine-lipoprotein complex).

Both inhibitors inhibit reactions involving the protein in which hemophilia A plasma is deficient (factor VIII).

Full Text

References

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