Deficiencies and Inhibitors of Thromboplastic Activity

Summary

The effects of hereditary deficiencies of thromboplastic proteins (hemophilia A and B) on the time course of thrombin appearance and disappearance in plasma (the thrombin activity curve, TAC) were compared with the effects of a naturally occurring gamma-globulin inhibitor of thromboplastic activity and with an anti-thromboplastic activity derived from cephalin (phosphatidylserine-lipoprotein complex).

Both inhibitors inhibit reactions involving the protein in which hemophilia A plasma is deficient (factor VIII).

^* Present address: Temple University Medical Center, Broad and Ontario Streets, Philadelphia, Pennsylvania.

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