Plasminogen Activation by Invasive Human Pathogens

Michael D P Boyle; Richard Lottenberg

doi:10.1055/s-0038-1655727

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1997; 77(01): 001-010
DOI: 10.1055/s-0038-1655727

Review Article

Schattauer GmbH Stuttgart

Plasminogen Activation by Invasive Human Pathogens^[*]

Michael D P Boyle

¹The Department of Microbiology, Medical College of Ohio, Toledo, Ohio, College of Medicine, Gainesville, Florida, USA

,

Richard Lottenberg

²The Division of Hematology/Oncology, Department of Medicine, University of Florida, College of Medicine, Gainesville, Florida, USA

› Author Affiliations

Abstract

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Summary

In this review the interaction between invasive human pathogens expressing plasmin(ogen) receptors and/or producing plasminogen activators with the human plasmin(ogen) system is described. Evidence is presented for multiple mechanisms by which human pathogens can acquire a surface bound form of plasmin that cannot be regulated by host serpins. The potential importance of these pathways in providing the organisms with the ability to cross tissue barriers is discussed.

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References

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Plasminogen Activation by Invasive Human Pathogens[*]

Plasminogen Activation by Invasive Human Pathogens^[*]