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Thromb Haemost 1997; 77(01): 087-093
DOI: 10.1055/s-0038-1655912
Coagulation
Schattauer GmbH Stuttgart

Family History of Coronary Heart Disease and Hemostatic Variables in Middle-Aged Adults

James S Pankow
1   The Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis
,
Aaron R Folsom
1   The Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis
,
Michael A Province
2   The Division of Biostatistics, Washington University School of Medicine, St. Louis
,
D C Rao
2   The Division of Biostatistics, Washington University School of Medicine, St. Louis
,
John Eckfeldt
3   The Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis
,
Gerardo Heiss
4   The Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill
,
Eyal Shahar
1   The Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis
,
Kenneth K Wu
5   The Division of Hematology-Oncology, University of Texas Medical School, Houston, USA
,
on behalf of the Atherosclerosis Risk in Communities Investigators and Family Heart Study Research Group › Author Affiliations
Further Information

Publication History

Received 27 February 1996

Accepted after revision 20 August 1996

Publication Date:
11 July 2018 (online)

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Summary

Individuals with a family history of coronary heart disease (CHD) may be predisposed to atherothrombosis. To investigate this hypothesis, a family CHD risk score was computed for approximately 13,000 men and women aged 45 to 64; hemostatic variables (fibrinogen, factor VIIc, factor VIIIc, von Willebrand factor, antithrombin III, protein C) were also measured in plasma. After adjustment for age and ethnicity, there was a statistically significant, positive association between the family risk score and four of the six hemostatic variables (fibrinogen, factor VIIc, factor VIIIc, von Willebrand factor) in women and all six hemostatic variables in men. In general, these associations were weak and substantially attenuated after adjustment for constitutional, lifestyle, and biochemical covariates. These results indicate that mean levels of selected hemostatic variables, like traditional CHD risk factors, are higher in individuals with a family history of heart disease.

 

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