The 10-Base-Pair Insertion in the Promoter of the Factor VII Gene Is not Associated with Lower Levels of Factor VI Ic in Afrocarribeans

Anne Temple; Le Ahn Luong; Kennedy Cruickshank; Steve E Humphries

doi:10.1055/s-0038-1655932

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1997; 77(01): 213-214
DOI: 10.1055/s-0038-1655932

Letter to the Editor

Schattauer GmbH Stuttgart

The 10-Base-Pair Insertion in the Promoter of the Factor VII Gene Is not Associated with Lower Levels of Factor VI Ic in Afrocarribeans

Anne Temple

¹The University College London, Department of Medicine, The Rayne Institute, London

,

Le Ahn Luong

¹The University College London, Department of Medicine, The Rayne Institute, London

,

Kennedy Cruickshank

²Clinical Epidemiology Unit, University of Manchester Medical School, Manchester, UK

,

Steve E Humphries

¹The University College London, Department of Medicine, The Rayne Institute, London

› Author Affiliations

Abstract

PDF Download

PDF (636 kb)

References

References
1 Rapaport SI, Rao LVM. Initiation and regulation of tissue factor-dependent blood coagulation. Thrombosis Council Distinguished Lecture. Arterioscler Thromb 1992; 02: 111-121
2 Meade TW, Mellows S, Brozovic M, Miller GJ, Chakrabarti RR, North WRS, Haines AP, Stirling Y, Imeson JD, Thompson SG. Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet 1986; 02: 533-537
3 Heinrich J, Balleisen L, Schulte H, Assmann G, van de LooJ. Fibrinogen and factor VII in the prediction of coronary risk. Results from the PROCAM study in healthy men. Arterioscler Thromb 1994; 14: 54-59
4 Meade TW, Ruddock V, Stirling Y, Chakrabarti R, Miller GJ. Fibrinolytic activity, clotting factors, and long-term incidence of ischaemic heart disease in the Northwick Park Heart Study. Lancet 1993; 342: 1076-1079
5 Humphries SE, Lane A, Green FR, Cooper J, Miller GJ. Factor VII coagulant activity and antigen levels in healthy men are determined by interaction between factor VII genotype and plasma triglyceride concentration. Arterioscler Thromb 1994; 14: 193-198
6 Lane A, Cruickshank JK, Stewart J, Henderson A, Humphries S, Green F. Genetic and environmental determinants of factor VII coagulant activity in ethnic groups at differing risk of coronary heart disease. Atherosclerosis 1992; 94: 43-50
7 Kario K, Narita N, Matsuo T, Kayaba K, Tsutsumi A, Matsuo M, Miyata T, Shimada K. Genetic determinants of plasma FVII activity in the Japanese. Thromb Haemost 1995; 73: 617-622
8 Arbini AA, Bauer KA. Reduced plasma factor VII coagulant activity due to the Arg353 gln polymorphism in the FII gene results from defective secretion. Blood 1994; 84: 86A (Abstract)
9 Humphries S, Temple A, Lane A, Green F, Cooper J, Miller G. Low plasma levels of factor VIIc are associated with both glutamine 353 variant and a 10 base pair promoter (-323) insertion. Thromb Haemost 1996; 75: 567-572
10 Bernardi F, Marchetti G, Pinotti M, Arcieri P, Baroncini C, Pappachini M, Zepponi E, Ursicino N, Chiarotti F, Mariani G. Factor VII gene polymorphisms contribute about one third of the factor VII level variation in plasma. Arterioscler Thromb Vase Biol 1996; 16: 72-76
11 Pollak ES, Hung H-L, Godin Willis, Overton GC, High KA. Functional characterisation of the human factor VII5’ flanking region. J Biol Chem 1996; 271: 1738-1747