Prevalence of Mutated Factor V ARG506 to GLN in Italians

Thromb Haemost 1997; 77(01): 216-217
DOI: 10.1055/s-0038-1655934

Letter to the Editor

Schattauer GmbH Stuttgart

V De Stefano

The Istituto Semeiotica Medica, Universitá Cattolica, Largo Gemelli 8,00168 Roma, Italy

,

M T Voso

The Istituto Semeiotica Medica, Universitá Cattolica, Largo Gemelli 8,00168 Roma, Italy

,

P Chiusolo

The Istituto Semeiotica Medica, Universitá Cattolica, Largo Gemelli 8,00168 Roma, Italy

,

K Paciaroni

The Istituto Semeiotica Medica, Universitá Cattolica, Largo Gemelli 8,00168 Roma, Italy

,

B Bizzi

The Istituto Semeiotica Medica, Universitá Cattolica, Largo Gemelli 8,00168 Roma, Italy

,

G Leone

The Istituto Semeiotica Medica, Universitá Cattolica, Largo Gemelli 8,00168 Roma, Italy

References
1 Mannucci PM, Duca F, Peyvandi F, Tagliabue L, Merati G, Martinelli I, Cattaneo M. Frequency of Factor V Arg506Gln in Italians. Thromb Haemost 1996; 75: 694
2 De Stefano V, Leone G. Resistance to activated protein C due to mutated Factor V as a novel cause of inherited thrombophilia. Haematologica 1995; 80: 346-358
3 Emmerich J, Poirier O, Evans A, Marques-Vidal P, Arveiler D, Luc G, Aiach M, Cambien F. Myocardial infarction, Arg 506 to Gin factor V mutation, and activated protein C resistance. Lancet 1995; 345: 321
4 Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-1134
5 Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, de RondeH, van der VeldenPA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-67
6 Simioni P, Prandoni P, Girolami A. Patients with AT III, protein C or protein S defects show no associated hereditary APC-resistance. Thromb Haemost 1994; 72: 481-482
7 Martinelli I, Magatelli R, Cattaneo M, Mannucci PM. Prevalence of mutant Factor V in Italian patients with hereditary deficiencies of antithrombin, protein C or protein S. Thromb Haemost 1996; 75: 694-695