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Thromb Haemost 1997; 77(02): 258-261
DOI: 10.1055/s-0038-1655949
Original Article
Schattauer GmbH Stuttgart

Factor V Leiden Is Not Common in Children with Portal Vein Thrombosis

C A Seixas
1   The Department of Pediatrics, São Francisco University, Bragança Paulista, SP, Brazil
,
G Hessel
2   The Department of Pediatrics, State University of Campinas, UNICAMP, Campinas, SP, Brazil
,
C C Ribeiro
3   Hematology-Hemotherapy Center, State University of Campinas, UNICAMP, Campinas, SP, Brazil
,
V R Arruda
3   Hematology-Hemotherapy Center, State University of Campinas, UNICAMP, Campinas, SP, Brazil
,
J M Annichino-Bizzacchi
3   Hematology-Hemotherapy Center, State University of Campinas, UNICAMP, Campinas, SP, Brazil
› Author Affiliations
Further Information

Publication History

Received 08 February 1996

Accepted after revision 08 October 1996

Publication Date:
10 July 2018 (online)

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Summary

Portal vein thrombosis (PVT) is a rare condition affecting both children and adults, and occurs in association with a wide variety of clinical situations. On the other hand, the development of PVT in patients under these situations indicates that other contributing factors could be envolved. Recently a missense mutation in the factor V gene (1691G→A), known as factor V Leiden, has been identified and results in abnormal factor V product, resistant to proteolytic inactivation by activated protein C and thus predisposes to thrombosis. This study was carried out to verify if children with PVT have an increase in frequency of factor V Leiden. Allele-specific restriction analysis and single strand conformational polymorphism (SSCP) were used to test for factor V Leiden in 20 children with PVT and 64 normal children. None of the PVT children were heterozygous or homozygous for the factor V Leiden, and one control child was heterozygous. This study demonstrates that factor V Leiden is not common in children with PVT, and is not a prerequisite for this thrombotic event.

 

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