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Thromb Haemost 1997; 77(03): 466-471
DOI: 10.1055/s-0038-1655990
Clinical Studies
Schattauer GmbH Stuttgart

Mild Hyperhomocysteinemia and Hemostatic Factors in Patients with Arterial Vascular Diseases

G Freyburger
1   The Laboratoire d'Hèmatologie, Hôpital Pellegrin, Bordeaux, France
,
S Labrouche
1   The Laboratoire d'Hèmatologie, Hôpital Pellegrin, Bordeaux, France
,
G Sassoust
3   The Service de Chirurgie Vasculaire, Hôpital Pellegrin, Bordeaux, France
,
F Rouanet
4   The Service de Neurologie, Hôpital Pellegrin, Bordeaux, France
,
S Javorschi
1   The Laboratoire d'Hèmatologie, Hôpital Pellegrin, Bordeaux, France
,
F Parrot
2   The Laboratoire de Biochimie, Hôpital Pellegrin, Bordeaux, France
› Author Affiliations
Further Information

Publication History

Received 16 July 1996

Accepted after resubmissions. 07 November 1996

Publication Date:
11 July 2018 (online)

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Summary

Mild hyperhomocysteinemia, due to genetic or to environmental factors, is now recognized as a risk factor for premature arterial disease, including peripheral arterial occlusion, thrombotic stroke and myocardial infarction. It is defined by either an increased level of fasting homocysteine or by an increased level after loading with methionine, which is more frequently altered than the former. We studied the hemostatic parameters in 88 patients with premature arterial disease (mean age 43 ± 11 years). We confirmed previously known hemostatic alterations described in vascular patients when compared to controls, but found that, among patients, some of these parameters were more altered in hyperhomocysteinemic patients. When fasting homocysteine was increased, higher alterations were found in factors VIIIc, von Wille- brand and thombin-antithrombin complexes were more elevated. When post-methionine load homocysteine was increased, alterations in fibrinolytic parameters were more pronounced.

 

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