Autoantibodies to Phospholipids and to the Coagulation Proteins in AIDS

N Abuaf; S Laperche; B Rajoely; R Carsique; A Deschamps; A M Rouquette; C Barthet; Z Khaled; C Marbot; N Saab; J Rozen; P M Girard; W Rozenbaum

doi:10.1055/s-0038-1656067

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1997; 77(05): 0856-0861
DOI: 10.1055/s-0038-1656067

Clinical Stydies

Schattauer GmbH Stuttgart

Autoantibodies to Phospholipids and to the Coagulation Proteins in AIDS

N Abuaf

¹The Service d'lmmunologie et d'Hématologie Biologique, Hôpital Rothschild, Paris, France

,

S Laperche

¹The Service d'lmmunologie et d'Hématologie Biologique, Hôpital Rothschild, Paris, France

,

B Rajoely

¹The Service d'lmmunologie et d'Hématologie Biologique, Hôpital Rothschild, Paris, France

,

R Carsique

¹The Service d'lmmunologie et d'Hématologie Biologique, Hôpital Rothschild, Paris, France

,

A Deschamps

¹The Service d'lmmunologie et d'Hématologie Biologique, Hôpital Rothschild, Paris, France

,

A M Rouquette

²Service d'Hématologie et d'lmmunologie Biologique, Hôpital Tenon, Paris, France

,

C Barthet

¹The Service d'lmmunologie et d'Hématologie Biologique, Hôpital Rothschild, Paris, France

,

Z Khaled

¹The Service d'lmmunologie et d'Hématologie Biologique, Hôpital Rothschild, Paris, France

,

C Marbot

¹The Service d'lmmunologie et d'Hématologie Biologique, Hôpital Rothschild, Paris, France

,

N Saab

¹The Service d'lmmunologie et d'Hématologie Biologique, Hôpital Rothschild, Paris, France

,

J Rozen

¹The Service d'lmmunologie et d'Hématologie Biologique, Hôpital Rothschild, Paris, France

,

P M Girard

³Service des Maladies Infectieuses et Tropicales, Hôpital Rothschild, Paris, France

,

W Rozenbaum

³Service des Maladies Infectieuses et Tropicales, Hôpital Rothschild, Paris, France

› Author Affiliations

Abstract

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Summary

In HIV-1 infection, an increased prevalence of anticardiolipin autoantibodies (aCL) and lupus anticoagulant (LA) has been described. In order to see if these antibodies are isolated or, like in autoimmune diseases, associated with hematological disorders and with antibodies to other phospholipids and to proteins of coagulation, we investigated 3 groups of patients: 1. 342 HIV-1 infected patients, 2. 145 control patients including 61 systemic lupus erythematosus (SLE) patients, 58 patients with a connective tissue disease, 15 patients with stroke, 11 patients with syphilis and 3.100 blood donors. In HIV-1 infection antiprothrombin (aPrT) antibodies were present in 25% of patients, the prevalence of antiphosphatidylcholine antibodies (aPC) (50%) was almost as high as aCL (64%), and 39% had both antibodies. Absorption on liposomes of the latter revealed an heterogeneous mixture of aCL and aPC or cross-reacting antibodies. In contrast with SLE, anti-β2-glycoprotein I (4%), LA (1%), biological false positive test for syphilis (0.3%), thrombosis (p <0.001) were uncommon. In HIV-1 infection, antiphospholipid antibodies do not associate with features linked to them in SLE or syphilis.

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References

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