Is There an Enhancing Effect of Neuroleptic Drugs on Blood Coagulation and Thrombosis

Summary

Sordinol (R), (clopenthixol, W.H. 0.), a potent sedative of the thiaxanthene group, in the concentrations used therapeutically, had no direct influence on blood coagulation as investigated by the thrombin generation test and the thromboplastin activation test. No significant direct effect on the fibrinolytic system was observed using urokinase, streptokinase activated human euglobulin, trypsin, porcine plasmin, or human plasmin. There was no effect on the urokinase-inhibiting effect of normal human plasma. The influence of the immobilization produced by heavy sedation on the development of thrombotic states is discussed. When the effects of drugs are evaluated it is necessary to distinguish between the direct effect of the drug and secondary effects caused by the treatment.

^* Present address: Department of Clinical Chemistry, Rigshospitalet, Copenhagen, Denmark.

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