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Thromb Haemost 1992; 68(03): 264-267
DOI: 10.1055/s-0038-1656362
Original Article
Schattauer GmbH Stuttgart

Activation of Coagulation and Fibrinolysis Following OKT3 Administration to Renal Transplant Recipients: Association with Distinct Mediators

Maarten H M Raasveld
1   The Renal Transplant Unit, Department of Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
2   The Clinical Immunology Laboratory, Department of Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
,
C Erik Hack
3   The Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and the Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands
,
Ineke J M ten Berge
1   The Renal Transplant Unit, Department of Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
2   The Clinical Immunology Laboratory, Department of Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 13 February 1992

Accepted after revision 21 April 1992

Publication Date:
04 July 2018 (online)

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Summary

Treatment with OKT3 induces cytokine release and activates the complement system. Since both phenomena may affect coagulation and fibrinolysis we studied these systems in 8 renal transplant recipients during OKT3 treatment. In 8 of 9 patients a similar pattern was observed: plasma thrombin-antithrombin-III-complex, tissue-type plasminogen-activator and plasmin-α2-antiplasmin-complex levels were increased as compared to pretreatment levels (p <0.05) at 15 min after the first OKT3 dose and reached peak values at 1 h. No significant changes were observed upon subsequent OKT3 administrations or in a control group of 8 patients. In one patient upon the first OKT3 administration only complement activation, and no cytokine release was observed, whereas plasma thrombin-antithrombin-III-complex, tissue-type plasminogen-activator and plasmin-α2-antiplasmin-complex levels increased only at 15 min.

In conclusion, we demonstrate a biphasic activation of coagulation and fibrinolysis upon the first OKT3 dose; the initial phase seems to be associated with complement activation, the later phase with cytokine release.

 

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