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Thromb Haemost 1992; 68(03): 306-309
DOI: 10.1055/s-0038-1656370
Original Article
Schattauer GmbH Stuttgart

Effect of DDAVP on Endotoxin-Induced Intravascular Coagulation in Rabbits

M J Paloma
The Hematology Service, University Clinic, Faculty of Medicine, University of Navarra, Pamplona, Spain
,
J A Páramo
The Hematology Service, University Clinic, Faculty of Medicine, University of Navarra, Pamplona, Spain
,
E Rocha
The Hematology Service, University Clinic, Faculty of Medicine, University of Navarra, Pamplona, Spain
› Author Affiliations
Further Information

Publication History

Received 18 September 1991

Accepted after revision 09 April 1992

Publication Date:
04 July 2018 (online)

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Summary

We have evaluated the effect of l-Deamino-8D-arginine vasopressin (DDAVP) on an experimental model of intravascular coagulation (DIC) induced in rabbits by injection of 20 µg kg–1 h–1 during 6 h of E. coli lipopolysaccharide. DDAVP significantly ameliorated the platelet drop and fibrinogen decrease (p <0.01) induced by endotoxin in control animals. A significant reduction in factor XII consumption (p <0.01) and a decrease in the generation of endotoxin induced PAI-1 activity in rabbits circulation was also observed (p <0.005). Moreover, fibrin deposition in kidneys of rabbits receiving DDAVP was significantly reduced as compared to control animals. Finally, the mortality rate in the control group was significantly higher than in DDAVP-treated rabbits (p <0.01). The hemostatic changes induced by DDAVP correlated with lower fibrin deposition and reduction in mortality rates.

 

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