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Thromb Haemost 1979; 42(03): 1009-1017
DOI: 10.1055/s-0038-1656991
Original Article
Schattauer GmbH Stuttgart

Factor-XII Congenital Deficiency. A New Family Study

J F Lucia
The Servicio Regional de Hematologia y Hemoterapia, Ciudad Sanitaria de la Seguridad Social, Zaragoza (Spain)
,
L Ercoreca
The Servicio Regional de Hematologia y Hemoterapia, Ciudad Sanitaria de la Seguridad Social, Zaragoza (Spain)
,
M Torres
The Servicio Regional de Hematologia y Hemoterapia, Ciudad Sanitaria de la Seguridad Social, Zaragoza (Spain)
,
M Giralt
The Servicio Regional de Hematologia y Hemoterapia, Ciudad Sanitaria de la Seguridad Social, Zaragoza (Spain)
,
A Raichs
The Servicio Regional de Hematologia y Hemoterapia, Ciudad Sanitaria de la Seguridad Social, Zaragoza (Spain)
› Author Affiliations
Further Information

Publication History

Received August 1978

Accepted 19 February 1979

Publication Date:
23 August 2018 (online)

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Summary

This report describes two people in a family with Hageman trait (homozygotes) (Factor XII = 0.06%). In addition eight family members were studied to evaluate the inheritance of this congenital deficiency. A study of the Kallikrein-Kininogen system induced by the fragments of Factor XII was also carried out.

It is concluded that the inheritance is as described by Veltkamp and that the Kallikrein release from the prekallikreinogen (Fletcher factor) “in vitro” is related to the amount of Factor XII procoagulant protein.

 

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