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Thromb Haemost 1979; 42(04): 1187-1192
DOI: 10.1055/s-0038-1657014
Original Article
Schattauer GmbH Stuttgart

Inhibition by N-Acetyl Neuraminic (Sialic) Acid of Platelet Aggregation Induced by Different Stimuli

Iren B Kovács
*   The »Koranyi« National Institute of Tuberculosis and Chest Diseases, H-124 Budapest, Hungary
,
P Görög
**   The Department of Pharmacology, EGYT-Pharmacochemical Works, H-1475 Budapest, Hungary
› Author Affiliations
Further Information

Publication History

Received 09 January 1979

Accepted 03 May 1979

Publication Date:
23 August 2018 (online)

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Summary

Addition of N-acetyl neuraminic acid (sialic acid, NANA) to citrated rat platelet-rich plasma significantly inhibited aggregation induced by near-threshold concentration of ADP, collagen or thrombin. In heparinized rat platelet-rich plasma aggregation of platelets induced by endotoxin or tumour cells of various origins was also inhibited by sialic acid.

It is suggested that exogenous or endogenous sialic acid may act against various aggregating stimuli on the platelet membrane by masking a common factor through which various aggregating agents exert their effect.

 

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