Prostacyclin Analogs: Antiaggregatory Potency and Enhancement of cAMP Levels in Human Platelet Rich Plasma

Thromb Haemost 1979; 42(04): 1340-1343
DOI: 10.1055/s-0038-1657030

Letter to the Editor

Schattauer GmbH Stuttgart

A Dembinska-Kiec

Zentrum für Pharmakologie u. Toxikologie, Medizinische Hochschule Hannover, D-3000 Hannover 61, Fed. Rep. Germany

,

W Rücker

Zentrum für Pharmakologie u. Toxikologie, Medizinische Hochschule Hannover, D-3000 Hannover 61, Fed. Rep. Germany

,

P S Schönhöfer

Zentrum für Pharmakologie u. Toxikologie, Medizinische Hochschule Hannover, D-3000 Hannover 61, Fed. Rep. Germany

,

C Gandolfi

Farmitalia Carlo Erba, Via Carlo Imbonati 24, 1-20159 Milan/Italy

References
1 Gilman AG. 1970; A protein binding assay for adenosine-3’, 5’-cyclic monophosphate. Proc. Nat. Acad. Sci. USA 67: 305
2 Gorman RR, Bunting S, Miller OV. 1977; Modulation of human platelet adenylate cyclase by prostacyclin (PGX). Prostaglandins 13: 377
3 Moncada S, Gryglewski RJ, Bunting S, Vane JR. 1976; An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature (London) 263: 663
4 Gryglewski RJ, Bunting S, Moncada S, Flower RJ, Vane RJ. 1976; Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides. Prostaglandins 12: 685