Cooperativity of Albumin and Aggrexons A and B for ADP-Induced-Aggregation of Platelets

Summary

Using extensively washed bovine platelets and a chemically defined medium instead of whole plasma, it was demonstrated that aggregation to a near normal extent was induced by ADP only in the presence of at least the following three components from plasma; albumin, Aggrexon A and Aggrexon B. These three proteins apparently acted cooperatively; the elimination of any one of the above mentioned plasma components from the system resulted in marked reduction of the aggregation.

• References

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