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Thromb Haemost 1979; 42(05): 1661-1666
DOI: 10.1055/s-0038-1657072
Symposium on Platelet Macromolecules
Schattauer GmbH Stuttgart

Observations on the “Cytoskeleton” of Human Platelets[*]

V T Nachmias
The Department of Anatomy, School of Medicine, University of Pennsylvania, Philadelphia, U.S.A.
,
J Sullender
The Department of Anatomy, School of Medicine, University of Pennsylvania, Philadelphia, U.S.A.
,
J Fallon
The Department of Anatomy, School of Medicine, University of Pennsylvania, Philadelphia, U.S.A.
,
A Asch
The Department of Anatomy, School of Medicine, University of Pennsylvania, Philadelphia, U.S.A.
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Publikationsdatum:
18. Februar 2019 (online)

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Summary

Structural study of rapidly lysed platelets supports the view that that shape change involves a change in state of the microfilaments which contain actin. The microtubule “bundle” appears to be a continuous coil. Proteolysis of a high molecular weight band is observed in platelets which can no longer form filopodia after suppression by local anesthetics.

* Presented at the VIth International Congress on Thrombosis and Haemostasis, Philadelphia, U.S.A.


 

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