Anticoagulation by Constant Subcutaneous Heparin Infusion

Summary

A preliminary clinical trial was conducted to determine the feasibility of achieving and regulating therapeutic anticoagulation with heparin given by continuous subcutaneous infusion. Five patients with deep venous thrombosis confirmed by impedance plethysmography and/or venography were studied. All patients received an initial heparin dose of 5000 units by IV bolus. This was followed by a continuous subcutaneous heparin infusion at a dose of 15 to 25 units per kilogram per hour. Effective levels of anticoagulation were achieved in all five patients. Regulation and maintenance of therapeutic anticoagulation were no more difficult than with intravenous therapy. No major complications were encountered during therapy.

Continuous subcutaneous infusion of heparin may have advantages over standard intravenous therapy or high dose intermittent subcutaneous therapy. However, more extensive clinical evaluation is warranted.

Key words

Anticoagulation - Heparin - Infusion device

• References

• 1 Teien AN, Lie M, Abildgaard U. Assay of heparin in plasma using a chromogenic substrate for activated Factor X. Thromb Res 1976; 2: 413-416
• 2 Salzman EW, Deykin D, Shapiro R. et al. Management of heparin therapy. N Engl J Med 1975; 292: 1046-1050
• 3 Martyn DT, Janes JM. Continuous intravenous administration of heparin. Mayo Clin Proc 1971; 46: 347-351