Summary
A preliminary clinical trial was conducted to determine the feasibility of achieving
and regulating therapeutic anticoagulation with heparin given by continuous subcutaneous
infusion. Five patients with deep venous thrombosis confirmed by impedance plethysmography
and/or venography were studied. All patients received an initial heparin dose of 5000
units by IV bolus. This was followed by a continuous subcutaneous heparin infusion
at a dose of 15 to 25 units per kilogram per hour. Effective levels of anticoagulation
were achieved in all five patients. Regulation and maintenance of therapeutic anticoagulation
were no more difficult than with intravenous therapy. No major complications were
encountered during therapy.
Continuous subcutaneous infusion of heparin may have advantages over standard intravenous
therapy or high dose intermittent subcutaneous therapy. However, more extensive clinical
evaluation is warranted.
Key words
Anticoagulation - Heparin - Infusion device
