Studies on the Activation Mechanism of Fibrinolytic Enzyme System in Plasma by Human Pancreatic Elastase

N Toki; S Takasugi; K Ishizu; H Sato; H Sumi

doi:10.1055/s-0038-1657114

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1982; 47(01): 008-013
DOI: 10.1055/s-0038-1657114

Original Article

Schattauer GmbH Stuttgart

Studies on the Activation Mechanism of Fibrinolytic Enzyme System in Plasma by Human Pancreatic Elastase

N Toki

^*The Department of Dermatology, Hiroshima University School of Medicine, Hiroshima, Japan

,

S Takasugi

^**The Department of Surgery, Hiroshima University School of Medicine, Hiroshima, Japan

,

K Ishizu

^*The Department of Dermatology, Hiroshima University School of Medicine, Hiroshima, Japan

,

H Sato

^***The Zeria Pharmaceutical Co., Ltd, Itabashi Lab., Tokyo, Japan

,

H Sumi

^****The Department of Physiology, Miyazaki Medical College, Miyazaki, Japan

› Author Affiliations

Abstract

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Summary

In the present study, the activation mechanism of fibrinolytic enzyme system in plasma by human pancreatic elastase was investigated. It was confirmed that human pancreatic elastase not only converted the co-existing plasminogen to low molecular weight-plasminogen which could be easily activated by the activator, but also inhibited α₂-macroglobulin and α₂-plasmin inhibitor which are antiactivators or fast reacting antiplasmins, and consequently, induced the activation of the fibrinolytic enzyme system in plasma.

Key words

Elastase - Pancreatitis - Plasmin - α₂-macroglobulin - α₂-plasmin inhibitor

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References

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