RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00035024.xml
Thromb Haemost 1982; 47(01): 66-68
DOI: 10.1055/s-0038-1657128
DOI: 10.1055/s-0038-1657128
Original Article
Successive Factor VIII Doses for a Haemophiliac Undergoing Major Surgery Calculated on a Microcomputer
Weitere Informationen
Publikationsverlauf
Received 25. Mai 1981
Accepted 05. Januar 1982
Publikationsdatum:
13. Juli 2018 (online)

Summary
Doses of factor VIII to be infused into a haemophiliac undergoing major surgery were calculated on a micro-computer. The degree to which the particular patient responded to infused factor VIII and the rate at which it decayed were estimated by two pre-operative experiments. Plasma levels of factor VIII were predicted over fourteen days during which time the patient was infused with 53,000 iu. A continuous plot of predicted values with time was displayed on a video monitor. The predicted values showed good agreement with assay results.
-
References
- 1 Johnson AJ, Karpatkin MargaretH, Newman J. Clinical Investigation of Intermediate- and High-Purity Antihaemophilic Factor (Factor VIII) Concentrates. Br J Haematol 1971; 21: 21-41
- 2 Snedecor GW, Cochran WG. In: Statistical Methods. 418-448 The Iowa State University Press: 1967
- 3 Austen DEG, Rhymes IL. In: A Laboratory Manual of Blood Coagulation. 50-52 Blackwell Scientific Publications; Oxford: 1975
- 4 Dasher FJ, Lyons JH, Finlayson DC, Shamsai J, Moore FD. Adv Surg. 1965; 1: 69-109
- 5 Allain J-P. Dose Requirement for Replacement Therapy in Haemophilia A. Thromb Haemostas 1979; 42: 825-831
- 6 Nilsson JM, Kirkwood TBL, Barrowcliffe TW. In Vivo Recovery of Factor VIII: A Comparison of One-stage and Two-stage Assay Methods. Thromb Haemostas 1979; 42: 1230-1239