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Thromb Haemost 1982; 47(03): 203-209
DOI: 10.1055/s-0038-1657168
Original Article
Schattauer GmbH Stuttgart

Role of Surface Negative Charge in Platelet Function Related to the Hyperreactive State in Estrogen-Treated Prostatic Carcinoma

Stephanie M Jung
The Division of Cardiovascular Research, The Tokyo Metropolitan Institute of Medical Science, Japan
,
Kenji Kinoshita
*   The Department of Urology, Tokyo Metropolitan Komagome Hospital, Japan
,
Kenjiro Tanoue
The Division of Cardiovascular Research, The Tokyo Metropolitan Institute of Medical Science, Japan
,
Ichiro Isohisa
The Division of Cardiovascular Research, The Tokyo Metropolitan Institute of Medical Science, Japan
,
Hiroh Yamazaki
The Division of Cardiovascular Research, The Tokyo Metropolitan Institute of Medical Science, Japan
› Author Affiliations
Further Information

Publication History

Received 13 October 1981

Accepted 15 March 1982

Publication Date:
13 July 2018 (online)

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Summary

The relationship between platelet surface negative charge and hyperfunction was examined by determining electrophoretic mobility (EPM), aggregability, and sialic acid of platelets in prostatic cancer, prostatic cancer with estrogen, prostatic cancer with estrogen and aspirin, prostatic hypertrophy, and healthy aged males. Estrogen treated prostatic cancer patients had significantly higher platelet EPM. A good linear correlation was found between sialic acid and EPM (r = 0.97, p <0.001). EPM was negatively correlated with primary aggregations by adrenaline and ADP but not with secondary or maximum aggregations, suggesting increased surface negative charge may inhibit primary aggregation. Estrogen and platelet population changes influenced surface negative charge. Neuraminidase removal of platelet surface sialic acid resulted in dose-dependent decreases of EPM which paralleled decreases in sialic acid. Aspirin treated patients and platelets incubated with aspirin in vitro both showed increased platelet EPM. These results suggest that platelet surface negative charge may directly affect platelet function.

Key words

Platelet electrophoretic mobility (EPM) - Surface negative charge - Estrogen - Prostatic cancer - Sialic acid
 

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