Thromboxane Synthetase Inhibition Results in Increased Platelet Sensitivity to Prostacyclin

Thromb Haemost 1982; 47(03): 294
DOI: 10.1055/s-0038-1657189

Letter to the Editor

Schattauer GmbH Stuttgart

Authors

Vittorio Bertelé

Istituto di Ricerche Farmacologiche, «Mario Negriu», Via Eritrea, 62, 20157 Milan, Italy
Anna Falanga

Istituto di Ricerche Farmacologiche, «Mario Negriu», Via Eritrea, 62, 20157 Milan, Italy
Maria Carla Roncaglioni

Istituto di Ricerche Farmacologiche, «Mario Negriu», Via Eritrea, 62, 20157 Milan, Italy
Chiara Cerletti

Istituto di Ricerche Farmacologiche, «Mario Negriu», Via Eritrea, 62, 20157 Milan, Italy
Giovanni de Gaetano

Istituto di Ricerche Farmacologiche, «Mario Negriu», Via Eritrea, 62, 20157 Milan, Italy

References
1 Bertelé V, Cerletti C, Schieppati A, Di Minno G, de Gaetano G. Inhibition of thromboxane synthetase does not necessarily prevent platelet aggregation. Lancet 1981; 1: 1057-1058
2 Bills TK, Smith JB, Silver MJ. Metabolism of [¹⁴C] arachidonic acid by human platelets. Biochim Biophys Acta 1976; 424: 303-314
3 Miller OV, Gorman RR. Evidence for distinct prostaglandin I₂ and D₂ receptors in human platelets. J Pharmacol Exp Ther 1979; 210: 134-140
4 de Gaetano G. Prostaglandin effects on platelets In: Abstracts, Prostaglandins in Cardiovascular and Thrombotic Disorders, Proc Symp Chicago. Illinois, May 7–9, 1981