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Thromb Haemost 1982; 47(03): 298
DOI: 10.1055/s-0038-1657193
Letter to the Editor
Schattauer GmbH Stuttgart

Additional Evidence for a Lack of Correlation Between Anticoagulant Activity and Phospholipid Hydrolysis by Snake Venom Phospholipases A2

Eleonora Condrea
1)   The Section of Pharmacology and Toxicology, Univer. of Connecticut, School of Pharmacy, Storrs, Ct. USA
3)   On leave of absence for the Rogoff-Wellcome Medical Research Institute, Tel-Aviv Univ. Medical School, Tel-Aviv, Israel
,
Chen-chung Yang
2)   The Inst. of Molecular Biology, National Tsing Hua Univer., Hsinchu. Taiwan, Republic of China
,
Philip Rosenberg
1)   The Section of Pharmacology and Toxicology, Univer. of Connecticut, School of Pharmacy, Storrs, Ct. USA
› Author Affiliations
Further Information

Publication History

Received 01 October 1981

Accepted 30 April 1982

Publication Date:
13 July 2018 (online)

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  • References

  • 1 Condrea E, Yang CC, Rosenberg P. Lack of correlation between anticoagulant activity and phospholipid hydrolysis by snake venom phospholipases A2 . Thromb Haemostas 1981; 45: 82-85
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  • 2 Condrea E, Fletcher JE, Rapuano BE, Yang CC, Rosenberg P. Dissociation of enzymatic activity from lethality and pharmacological properties by carbamylation of lysines in Naja nigricollis and Naja naja atra snake venom phospholipases A2 . Toxicon 1981; 19: 705-720
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  • 3 Verheji HM, Boffa MC, Rothen C, Bryckaert MC, Verger R, DeHaas GH. Correlation of enzymatic activity and anticoagulant properties of phospholipases A2 . Eur J Biochem 1980; 112: 25-32
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  • 4 Yang CC, King K, Sun TP. Chemical modification of lysine and histidine residues in phospholipase A2 from the venom of Naja naja atra. Toxicon 1981; 19: 645-659
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