Additional Evidence for a Lack of Correlation Between Anticoagulant Activity and Phospholipid Hydrolysis by Snake Venom Phospholipases A2

Thromb Haemost 1982; 47(03): 298
DOI: 10.1055/s-0038-1657193

Letter to the Editor

Schattauer GmbH Stuttgart

Additional Evidence for a Lack of Correlation Between Anticoagulant Activity and Phospholipid Hydrolysis by Snake Venom Phospholipases A₂

Eleonora Condrea

¹⁾The Section of Pharmacology and Toxicology, Univer. of Connecticut, School of Pharmacy, Storrs, Ct. USA

³⁾On leave of absence for the Rogoff-Wellcome Medical Research Institute, Tel-Aviv Univ. Medical School, Tel-Aviv, Israel

,

Chen-chung Yang

²⁾The Inst. of Molecular Biology, National Tsing Hua Univer., Hsinchu. Taiwan, Republic of China

,

Philip Rosenberg

¹⁾The Section of Pharmacology and Toxicology, Univer. of Connecticut, School of Pharmacy, Storrs, Ct. USA

References
1 Condrea E, Yang CC, Rosenberg P. Lack of correlation between anticoagulant activity and phospholipid hydrolysis by snake venom phospholipases A₂ . Thromb Haemostas 1981; 45: 82-85
2 Condrea E, Fletcher JE, Rapuano BE, Yang CC, Rosenberg P. Dissociation of enzymatic activity from lethality and pharmacological properties by carbamylation of lysines in Naja nigricollis and Naja naja atra snake venom phospholipases A₂ . Toxicon 1981; 19: 705-720
3 Verheji HM, Boffa MC, Rothen C, Bryckaert MC, Verger R, DeHaas GH. Correlation of enzymatic activity and anticoagulant properties of phospholipases A₂ . Eur J Biochem 1980; 112: 25-32
4 Yang CC, King K, Sun TP. Chemical modification of lysine and histidine residues in phospholipase A₂ from the venom of Naja naja atra. Toxicon 1981; 19: 645-659