In Vivo Interactions of Autoantibodies to Factor VIII with the Factor VIII Complex

J P Allain; M P Croissant; D Lerolle; L Houbouyan; M Zuzel; D Frommel

doi:10.1055/s-0038-1657243

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1982; 48(02): 142-145
DOI: 10.1055/s-0038-1657243

Original Article

Schattauer GmbH Stuttgart

In Vivo Interactions of Autoantibodies to Factor VIII with the Factor VIII Complex

J P Allain

The Centre National de Transfusion Sanguine, and INSERM, Paris, France

,

M P Croissant

The Centre National de Transfusion Sanguine, and INSERM, Paris, France

,

D Lerolle

The Centre National de Transfusion Sanguine, and INSERM, Paris, France

,

L Houbouyan

The Centre National de Transfusion Sanguine, and INSERM, Paris, France

,

M Zuzel

The Centre National de Transfusion Sanguine, and INSERM, Paris, France

,

D Frommel

The Centre National de Transfusion Sanguine, and INSERM, Paris, France

› Institutsangaben

Abstract

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Summary

Two non-haemophilic elderly patients who had developed autoantibodies to factor VIII were studied over a period of 9 months to 5 years. Sequential measurements of antibody to factor VIII (anti-VIII: C), factor VIII coagulant activity (VIII: C), factor VIII coagulant antigen (VIII: CAg), factor VIII-related antigen (VIIIR: Ag), and factor VIII ristocetin cofactor (VIII: WF) were performed. Before treatment, low VIII: C, norlnal or increased VIII: CAg and high VIIIR: Ag levels were found and were indicative of the presence of circulating immune complexes. Immunosuppressive therapy induced progressive correction of VIII: C and VIIIR: Ag values. High levels of VIII: CAg subsided in the patient who relapsed. It is suggested that antibodies to factor VIII bind and remove VIII: C from the circulation thereby inducing an increased synthesis of VIII: CAg which may be associated with an augmented release or production of VIIIR: Ag.

Keywords

Autoantibody - Acquired haemophilia - Factor VIII complex - IRMA - Immunosuppressive therapy

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Referenzen

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