The Basis for the Increase in Factor VIII Procoagulant Activity During Exercise

Robert G Kopitsky; Mary Ellen P Switzer; R Sanders Williams; Patrick A McKee

doi:10.1055/s-0038-1657315

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1983; 49(01): 053-057
DOI: 10.1055/s-0038-1657315

Original Article

Schattauer GmbH Stuttgart

The Basis for the Increase in Factor VIII Procoagulant Activity During Exercise

Robert G Kopitsky

The Howard Hughes Medical Institute Laboratories, Department of Medicine and the Department of Biochemistry, Duke University Medical Center, Durham NC, U.S.A.

,

Mary Ellen P Switzer

The Howard Hughes Medical Institute Laboratories, Department of Medicine and the Department of Biochemistry, Duke University Medical Center, Durham NC, U.S.A.

,

R Sanders Williams

The Howard Hughes Medical Institute Laboratories, Department of Medicine and the Department of Biochemistry, Duke University Medical Center, Durham NC, U.S.A.

,

Patrick A McKee

The Howard Hughes Medical Institute Laboratories, Department of Medicine and the Department of Biochemistry, Duke University Medical Center, Durham NC, U.S.A.

› Author Affiliations

Abstract

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Summary

We studied the effect of acute exercise on the ability of thrombin to activate plasma factor VIII (FVIII) activity in 20 healthy males. The subject showed an average exercise-related increase in FVIII activity of 54.5±8.2% over pre-exercise FVIII activity (p<0.001). When exposed to the same concentration of thrombin, post-exercise FVIII activity showed greater enhancement than pre-exercise FVIII activity: 157.1±12.8% increase in activity versus 117.3±9.9%, respectively (p<0.01). The degree of the potentiated thrombin effect in post-exercise samples relative to pre-exercise samples was linearly correlated with the degree of the exercise-related increase in FVIII activity. Taken together with our previous observations that the extent of thrombin enhancement of FVIII activity varies inversely with the mole ratio of FVIII/von Willebrand factor subunits to thrombin, these findings imply that release of FVIII does not occur during exercise, and that the exercise-related increase in FVIII activity results primarily, if not completely, from activation of already circulating but inactive FVIII.

Keywords

FVIII/vWF - Factor VIII/von Willebrand factor - Exercise and factor VIII activity increase - Thrombin and factor VIII

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References

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