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Thromb Haemost 1983; 49(02): 102-105
DOI: 10.1055/s-0038-1657331
DOI: 10.1055/s-0038-1657331
Original Article
The Half Life of Factor XIII in the Management of Inherited Deficiency
Weitere Informationen
Publikationsverlauf
Received 06. Dezember 1982
Accepted 26. Januar 1983
Publikationsdatum:
18. Juli 2018 (online)
Summary
Following the injection of a large dose of factor XIII concentrate the in vivo half life of factor XIII was estimated in a patient with inherited deficiency. Factor XIII activity and enzyme concentration were measured quantitatively, and a qualitative assessment of the crosslinking of fibrin was also made for upto 6 weeks after the injection. The half life was found to be about 9-10 days. This is longer than most previous reports suggest. An explanation for this finding is offered. The relevance of the long half life of factor XIII to the prophylactic treatment of patients with inherited deficiency is demonstrated.
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