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Thromb Haemost 1983; 49(02): 120-122
DOI: 10.1055/s-0038-1657335
Original Article
Schattauer GmbH Stuttgart

A New Dysfibrinogenemia: Fibrinogen Oslo IV

H Stormorken
The Research Institute for Internal Medicine, Rikshospitalet, Oslo, the Department of Lung Diseases, Rikshospitalet, Oslo, Norway
,
F Brosstad
The Research Institute for Internal Medicine, Rikshospitalet, Oslo, the Department of Lung Diseases, Rikshospitalet, Oslo, Norway
,
H Seim
The Research Institute for Internal Medicine, Rikshospitalet, Oslo, the Department of Lung Diseases, Rikshospitalet, Oslo, Norway
› Author Affiliations
Further Information

Publication History

Received 20 September 1982

Accepted 08 February 1983

Publication Date:
18 July 2018 (online)

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Summary

A family with dysfibrinogenemia is described. The abnormal fibrinogen occurred in three successive generations indicating a dominant hereditary pattern. Thrombin and reptilase times were about twice the normal value. This was shown to be caused by a polymerization defect, fibrinopeptide release being normal. Platelet aggregation was undisturbed, indicating normal platelet-fibrinogen binding. The bleeding time was normal and there was no bleeding tendency. However, an obscure recurrent pulmonary ailment may, or may not, be related to the dysfibrinogenemia. The abnormal fibrinogen was tentatively termed Oslo IV.

Keywords

Dysfibrinogenemia - Polymerization defect - Inheritable
 

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