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DOI: 10.1055/s-0038-1657354
Platelet Abnormalities in Muscular Dystrophy
Publication History
Received 12 February 1982
Accepted 17 March 1983
Publication Date:
18 July 2018 (online)
Summary
Platelets which have complex membranes and calcium shifts similar to those in muscles were investigated in 14 patients with muscular dystrophy and 20 suitable controls. In 4 Duchenne and one limb-girdle dystrophy aggregations were done and found to be depressed with adrenaline and ADP. Electron microscopic and chemical examinations revealed an increased number of dense bodies, changed permeability and/or binding of cations and elevated intracellular calcium in all the 9 cases of Duchenne dystrophy while the 2 limb-girdle and 3 myotonic dystrophies varied.
A two phase polymer separation system applied to fixed platelets of all patients and controls showed no abnormality of surface negative charge.
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