Download PDF
Thromb Haemost 1997; 78(01): 112-116
DOI: 10.1055/s-0038-1657511
Understanding the initiation of blood coagulation
Schattauer GmbH Stuttgart

Factor VIIa-Tissue Factor: Functional Importance of Protein-Membrane Interactions

James H Morrissey
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK; Pathology Department, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Departments of Medical Biochemistry and Genetics, Chemistry, and Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA
,
Pierre F Neuenschwander
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK; Pathology Department, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Departments of Medical Biochemistry and Genetics, Chemistry, and Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA
,
Qiuling Huang
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK; Pathology Department, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Departments of Medical Biochemistry and Genetics, Chemistry, and Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA
,
Christine D McCallum
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK; Pathology Department, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Departments of Medical Biochemistry and Genetics, Chemistry, and Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA
,
Bixia Su
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK; Pathology Department, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Departments of Medical Biochemistry and Genetics, Chemistry, and Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA
,
Arthur E Johnson
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK; Pathology Department, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Departments of Medical Biochemistry and Genetics, Chemistry, and Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA
› Author Affiliations
Further Information

Publication History

Publication Date:
12 July 2018 (online)

Also available at
  PDF Download  Permissions and Reprints
 

  • References

  • 1 Banner DW, D’Arcy A, Chène C, Winkler FK, Guha A, Konigsberg WH, Nemerson Y, Kirchhofer D. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature 1996; 380: 41-46
    CrossrefPubMedGoogle Scholar
  • 2 Carson SD, Brozna JP. The role of tissue factor in the production of thrombin. Blood Coag Fibrinol 1993; 04: 281-292
    CrossrefPubMedGoogle Scholar
  • 3 Drake TA, Morrissey JH, Edgington TS. Selective cellular expression of tissue factor in human tissues: Implications for disorders of hemostasis and thrombosis. Am J Pathol 1989; 134: 1087-1097
    PubMedGoogle Scholar
  • 4 Fleck RA, Rao LVM, Rapaport SI, Varki N. Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody. ThiombRes 1990; 57: 765-781
    PubMedGoogle Scholar
  • 5 Bom VJJ, Bertina RM. The contributions of Ca2+, phospholipids and tissue-factor apoprotein to the activation of human blood-coagulation Factor X by activated Factor VII. Biochem J 1990; 265: 327-336
    CrossrefPubMedGoogle Scholar
  • 6 Komiyama Y, Pedersen AH, Kisiel W. Proteolytic activation of human factors IX and X by recombinant human factor VIIa: Effects of calcium, phospholipids, and tissue factor. Biochemistry 1990; 29: 9418-9425
    CrossrefPubMedGoogle Scholar
  • 7 Muller YA, Ultsch MH, Kelley RF, De VosAM. Structure of the extracellular domain of human tissue factor: Location of the factor VIIa binding site. Biochemistry 1994; 33: 10864-10870
    CrossrefPubMedGoogle Scholar
  • 8 Harlos K, Martin DMA, O’Brien DP, Jones EY, Stuart Dl, Polikarpov I, Miller A, Tuddenham EGD, Boys CWG. Crystal structure of the extracellular region of human tissue factor. Nature 1994; 370: 662-666
    CrossrefPubMedGoogle Scholar
  • 9 Paborsky LR, Caras IW, Fisher KL, Gorman CM. Lipid association, but not the transmembrane domain, is required for tissue factor activity. Substitution of the transmembrane domain with a phosphatidylinositol anchor. J Biol Chem 1991; 266: 21911-21916
    PubMedGoogle Scholar
  • 10 Ruf W, Rehemtulla A, Edgington TS. Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function. J Biol Chem 1991; 266: 2158-2166
    PubMedGoogle Scholar
  • 11 Shigematsu Y, Miyata T, Higashi S, Miki T, Sadler JE, Iwanaga S. Expression of human soluble tissue factor in yeast and enzymatic properties of its complex with factor VIIa. J Biol Chem 1992; 267: 21329-21337
    PubMedGoogle Scholar
  • 12 Waxman E, Ross JBA, Laue TM, Guha A, Thiruvikraman SV, Lin TC, Konigsberg WH, Nemerson Y. Tissue factor and its extracellular soluble domain: The relationship between inter-molecular association with factor VIIa and enzymatic activity of the complex. Biochemistry 1992; 31: 3998-4003
    CrossrefPubMedGoogle Scholar
  • 13 Rezaie AR, Fiore MM, Neuenschwander PF, Esmon CT, Morrissey JH. Expression and purification of a soluble tissue factor fusion protein with an epitope for an unusual calcium-dependent antibody. Protein Express Purif 1992; 03: 453-460
    CrossrefPubMedGoogle Scholar
  • 14 Waxman E, Laws WR, Laue TM, Nemerson Y, Ross JBA. Human factor VIIa and its complex with soluble tissue factor: Evaluation of asymmetry and conformational dynamics by ul-tracentrifiigation and fluorescence anisotropy decay methods. Biochemistry 1993; 32: 3005-3012
    CrossrefPubMedGoogle Scholar
  • 15 Neuenschwander PF, Morrissey JH. Deletion of the membrane anchoring region of tissue factor abolishes autoactivation of factor VII but not cofactor function. Analysis of a mutant with a selective deficiency in activity. J Biol Chem 1992; 267: 14477-14482
    PubMedGoogle Scholar
  • 16 Neuenschwander PF, Morrissey JH. Roles of the membrane-interactive regions of factor VIIa and tissue factor. The factor VIIa Gla domain is dispensable for binding to tissue factor but important for activation of factor X. J Biol Chem 1994; 269: 8007-8013
    PubMedGoogle Scholar
  • 17 Hagen FS, Gray CL, O’Hara P, Grant FJ, Saari GC, Woodbury RG, Hart CE, Insley M, Kisiel W, Kurachi K, Davie EW. Characterization of a cDNA coding for human factor VII. Proc Natl Acad Sci USA 1986; 83: 2412-2416
    CrossrefPubMedGoogle Scholar
  • 18 Wildgoose P, Jorgensen T, Komiyama Y, Nakagaki T, Pedersen A, Kisiel W. The role of phospholipids and the factor VII Gla-domain in the interaction of factor VII with tissue factor. Thromb Haemost 1992; 67: 679-685
    Article in Thieme ConnectPubMedGoogle Scholar
  • 19 Persson E, Petersen LC. Structurally and functionally distinct Ca2+ binding sites in the gamma-carboxyglutamic acid-containing domain of factor VIIa. Eur J Biochem 1995; 234: 293-300
    CrossrefPubMedGoogle Scholar
  • 20 Schiodt J, Harrit N, Christensen U, Petersen LC. Two different Ca2+ ion binding sites in factor VIIa and in des(l-38) factor VIIa. FEBS Lett 1992; 306: 265-268
    CrossrefPubMedGoogle Scholar
  • 21 Wildgoose P, Foster D, Schiodt J, Wiberg FC, Birktoft JJ, Petersen LC. Identification of a calcium binding site in the protease domain of human blood coagulation factor VII: Evidence for its role in factor VII-tissue factor interaction. Biochemistry 1993; 32: 114-119
    CrossrefPubMedGoogle Scholar
  • 22 Freskgård PO, Olsen OH, Persson E. Structuralchanges in factor VIIa induced by Ca2+ and tissue factor studied using circular dichroism spectroscopy. Protein Sci 1996; 05: 1531-1540
    CrossrefPubMedGoogle Scholar
  • 23 McCallum CD, Hapak RC, Neuenschwander PF, Morrissey JH, Johnson AE. The location of the active site of blood coagulation factor VIIa above the membrane surface and its reorientation upon association with tissue factor -A fluorescence energy transfer study. J Biol Chem 1996; 271: 28168-28175
    CrossrefPubMedGoogle Scholar
  • 24 Husten EJ, Esmon CT, Johnson AE. The active site of blood coagulation factor Xa. Its distance from the phospholipid surface and its conformational sensitivity to components of the prothrombinase complex. J Biol Chem 1987; 26212953-26212961
    PubMedGoogle Scholar
  • 25 Nemerson Y. The phospholipid requirement of tissue factor in blood coagulation. J Clin Invest 1968; 47: 72-80
    CrossrefPubMedGoogle Scholar
  • 26 Liu DTH, McCoy LE. Phospholipid requirement of tissue thromboplastin in blood coagulation. Thromb Res 1975; 07: 213-221
    CrossrefPubMedGoogle Scholar
  • 27 Rouser G, White S, Schloredt D. Phospholipid structure and thromboplastic activity. I. The phosphatide fraction active in recalcified normal human plasma. Biochim Biophys Acta 1950; 28: 71-80
    PubMedGoogle Scholar
  • 28 Rouser G. Phospholipid structure and thromboplastic activity II. The fatty acid composition of the active phosphatidyl ethanolamines. Biochim Biophys Acta 1958; 28: 81-87
    CrossrefPubMedGoogle Scholar
  • 29 Wallach DFH, Maurice PA, Steele BB, Surgenor DM. Studies on the relationship between the colloidal state and clot-promoting activity of pure phosphatidylethanolamines. J Biol Chem 1959; 234: 2829-2834
    PubMedGoogle Scholar
  • 30 Nemerson Y. Characteristics and lipid requirements of coagulant proteins extracted from lung and brain: The specificity of the protein component of tissue factor. J Clin Invest 1969; 48: 322-331
    CrossrefPubMedGoogle Scholar
  • 31 Cutsforth GA, Whitaker RN, Hermans J, Lentz BR. A new model to describe extrinsic protein binding to phospholipid membranes of varying composition: Application to human coagulation proteins. Biochemistry 1989; 28: 7453-7461
    CrossrefPubMedGoogle Scholar
  • 32 Rauch J, Janoff AS. The nature of antiphospholipid antibodies. J Rheumatol 1992; 19: 1782-1785
    PubMedGoogle Scholar
  • 33 Smirnov MD, Esmon CT. Phosphatidylethanolamine incorporation into vesicles selectively enhances factor Va inactivation by activated protein C. J Biol Chem 1994; 269: 816-819
    CrossrefPubMedGoogle Scholar
  • 34 Neuenschwander PF, Bianco-Fisher E, Rezaie AR, Morrissey JH. Phosphatidylethanolamine augments factor VIIa-tissue factor activity: Enhancement of sensitivity to phosphatidylserine. Biochemistry 1995; 34: 13988-13993
    CrossrefPubMedGoogle Scholar
  • 35 Bevers EM, Comfurius P, Zwaal RFA. Changes in membrane phospholipid distribution during platelet activation. Biochim Biophys Acta 1983; 736: 57-66
    CrossrefPubMedGoogle Scholar
  • 36 Nakagaki T, Foster DC, Berkner KL, Kisiel W. Initiation of the extrinsic pathway of blood coagulation: Evidence for the tissue factor dependent autoactivation of human coagulation factor VII. Biochemistry 1991; 30: 10819-10824
    CrossrefPubMedGoogle Scholar
  • 37 Neuenschwander PF, Fiore MM, Morrissey JH. Factor VII autoactivation proceeds via interaction of distinct protease-co-factor and zymogen-cofactor complexes. Implications of a twodimensional enzyme kinetic mechanism. J Biol Chem 1993; 268: 21489-21492
    PubMedGoogle Scholar
  • 38 Fiore MM, Neuenschwander PF, Morrissey JH. The biochemical basis for the apparent defect of soluble mutant tissue factor in enhancing the proteolytic activities of factor VIIa. J Biol Chem 1994; 269: 143-149
    PubMedGoogle Scholar
  • 39 Morrissey JH, Macik BG, Neuenschwander PF, Comp PC. Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation. Blood 1993; 81: 734-744
    PubMedGoogle Scholar
  • 40 Morrissey JH. Tissue factor modulation of factor VIIa activity: Use in measuring trace levels of factor Vila in plasma. Thromb Haemost 1995; 74: 185-188
    Article in Thieme ConnectPubMedGoogle Scholar
  • 41 Nelsestuen GL, Kisiel W, Di ScipioRG. Interaction of vitamin K dependent proteins with membranes. Biochemistry 1978; 172134-172138
    PubMedGoogle Scholar
  • 42 Petersen LC, Schiodt J, Christensen U. Involvement of the hydrophobic stack residues 39-44 of factor VIIa in tissue factor interactions. FEBS Lett 1994; 347: 73-79
    CrossrefPubMedGoogle Scholar
  • 43 Martin DMA, O’Brien DP, Tuddenham EGD, Byfield PGH. Synthesis and characterization of wild-type and variant gamma-carboxyglutamic acid-containing domains of factor VII. Biochemistry 1993; 32: 13949-13955
    CrossrefPubMedGoogle Scholar
  • 44 Rezaie AR, Neuenschwander PF, Morrissey JH, Esmon CT. Analysis of the functions of the first epidermal growth factor-like domain of factor X. J Biol Chem 1993; 268: 8176-8180
    PubMedGoogle Scholar
  • 45 Roy S, Hass PE, Bourell JH, Henzel WJ, Vehar GA. Lysine residues 165 and 166 are essential for the cofactor function of tissue factor. J Biol Chem 1991; 266: 22063-22066
    PubMedGoogle Scholar
  • 46 Ruf W, Miles DJ, Rehemtulla A, Edgington TS. Cofactor residues lysine 165 and 166 are critical for protein substrate recognition by the tissue factor-factor VIIa protease complex. J Biol Chem 1992; 267: 6375-6381
    PubMedGoogle Scholar
  • 47 Huang QL, Neuenschwander PF, Rezaie AR, Morrissey JH. Substrate recognition by tissue factor-factor VIIa - Evidence for interaction of residues Lys165 and Lys166 of tissue factor with the 4-carboxyglutamate-rich domain of factor X. J Biol Chem 1996; 271: 21752-21757
    CrossrefPubMedGoogle Scholar