The Structural Basis of Function of the TF●VIIa Complex in the Cellular Initiation of Coagulation

Thomas S Edgington; Craig D Dickinson; Wolfram Ruf

doi:10.1055/s-0038-1657560

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1997; 78(01): 401-405
DOI: 10.1055/s-0038-1657560

Cytokines and thrombosis

Schattauer GmbH Stuttgart

The Structural Basis of Function of the TF●VIIa Complex in the Cellular Initiation of Coagulation

Thomas S Edgington

Departments of Immunology and Vascular Biology, The Scripps Research Institute, La Jolla, CA, USA

,

Craig D Dickinson

Departments of Immunology and Vascular Biology, The Scripps Research Institute, La Jolla, CA, USA

,

Wolfram Ruf

Departments of Immunology and Vascular Biology, The Scripps Research Institute, La Jolla, CA, USA

› Institutsangaben

Abstract

als PDF herunterladen

PDF (442 kb)

Referenzen

References
1 Taylor J, Chang A, Ruf W, Morrissey JH, Hinshaw L, Catlett R, Blick K, Edgington TS. Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody. Circulatory Shock 1991; 33: 127-134
2 Moreno PR, Bemardi VH, López-Cuéllar J, Murcia AM, Palacios IF, Gold HK, Mehran R, Sharma SK, Nemerson Y, Fuster V, Fallon JT. Macrophages, smooth muscle cells, and tissue factor in unstable angina – Implications for cell-mediated thrombogenicity in acute coronary syndromes. Circulation 1996; 94: 3090-3097
3 Carmeliet P, Mackman N, Moons L, Luther T, Gressens P, Van Vlaenderen I, Demunck H, Kasper M, Breier G, Evrard P, Muller M, Risau W, Edgington T, Collen D. Role of tissue factor in embryonic blood vessel development. Nature 1996; 383: 73-75
4 Ruf W, Mueller BM. Tissue factor in cancer angiogenesis and metastasis. Curr Opin Hematol 1996; 03: 379-384
5 Sevinsky JR, Rao LVM, Ruf W. Ligand-induced protease receptor translocation into caveolae: A mechanism for regulating cell surface proteolysis of the tissue factor-dependent coagulation pathway. J Cell Biol 1996; 133: 293-304
6 Harlos K, Martin DMA, O’Brien DP, Jones EY, Stuart DI, Polikarpov I, Miller A, Tuddenham EGD, Boys CWG. Crystal structure of the extracellular region of human tissue factor. Nature 1994; 370: 662-666
7 Muller YA, Ultsch MH, Kelley RF, De Vos AM. Structure of the extracellular domain of human tissue factor: location of the factor VIIa binding site. Biochemistry 1994; 33: 10864-10870
8 Banner DW, D’Arcy A, Chène C, Winkler FK, Guha A, Konigsberg WH, Nemerson Y, Kirchhofer D. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature 1996; 380: 41-46
9 Clackson T, Wells J. A hot spot of binding energy in a hormone-receptor interface. Science 1995; 267: 383-386
10 Dickinson CD, Kelly CR, Ruf W. Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa. Proc Natl Acad Sci USA 1996; 93: 14379-14384
11 Schullek JR, Ruf W, Edgington TS. Key ligand interface residues in tissue factor contribute independently to factor VIIa binding. J Biol Chem 1994; 269: 19399-19403
12 Kelly CR, Schullek JR, Ruf W, Edgington TS. Tissue factor residue Asp⁴⁴regulates catalytic function of the bound protease factor VIIa. Biochem J 1996; 315: 145-151
13 Di Cera E, Guinto ER, Vindigni A, Dang QD, Ayala YM, Wuyi M, Tulinsky A. The Na⁺binding site of thrombin. J Biol Chem 1995; 270: 22089-22092
14 Huber R, Bode W. Structural basis of the activation and action of trypsin. Accounts of Chemical Research 1978; 11: 114-122
15 Higashi S, Nishimura H, Aita K, Iwanaga S. Identification of regions of bovine factor VII essential for binding to tissue factor. J Biol Chem 1994; 269: 18891-18898
16 Wildgoose P, Foster D, Schiodt J, Wiberg FC, Birktoft JJ, Petersen LC. Identification of a calcium binding site in the protease domain of human blood coagulation factor VII: Evidence for its role in factor VII-tissue factor interaction. Biochemistry 1993; 32: 114-119
17 Ruf W. Factor VIIa residue Arg²⁹⁰is required for efficient activation of the macromolecular substrate factor X. Biochemistry 1994; 33: 11631-11636
18 Ruf W, Edgington TS. An anti-tissue factor monoclonal antibody which inhibits TF:VIIa complex is a potent anticoagulant in plasma. Thromb Haemost 1991; 66: 529-533
19 Ruf W, Miles DJ, Rehemtulla A, Edgington TS. Cofactor residues lysine 165 and 166 are critical for protein substrate recognition by the tissue factor-factor VIIa protease complex. J Biol Chem 1992; 267: 6375-6381
20 Huang QL, Neuenschwander PF, Rezaie AR, Morrissey JH. Substrate recognition by tissue factor-factor VIIa — Evidence for interaction of residues Lys¹⁶⁵and Lys¹⁶⁶of tissue factor with the 4-carboxyglutamate-rich domain of factor X. J Biol Chem 1996; 271: 21752-21757
21 Watzke HH, Lechner K, Roberts HR, Reddy SV, Welsch DJ, Friedman P, Mahr G, Jagadeeswaran P, Monroe DM, High KA. Molecular defect (Gla⁺¹⁴→Lys) and its functional consequences in a hereditary factor X deficiency (factor X “Vorarlberg”). J Biol Chem 1990; 265: 11982-11989
22 Rao LVM, Ruf W. Tissue factor residues Lysl65 and Lysl66 are essential for rapid formation of the quaternary complex of tissue factor-VIIa with Xa-tissue factor pathway inhibitor. Biochemistry 1995; 34: 10867-10871
23 Ruf W, Kalnik MW, Lund-Hansen T, Edgington TS. Characterization of factor VII association with tissue factor in solution. High and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions. J Biol Chem 1991; 266: 15719-15725
24 Dittmar S, Ruf W, Edgington TS. Influence of mutations in tissue factor on the fine specificity of macromolecular substrate activation. Biochem J 1997; 321: 787-793
25 Ruf W, Schullek JR, Stone MJ, Edgington TS. Mutational mapping of functional residues in tissue factor: Identification of factor VII recognition determinants in both structural modules of the predicted cytokine receptor homology domain. Biochemistry 1994; 33: 1565-1572
26 Ruf W, Kelly CR, Schullek JR, Martin DMA, Polikarpov I, Boys CWG, Tuddenham EGD, Edgington TS. Energetic contributions and topographical organization of ligand binding residues of tissue factor. Biochemistry 1995; 34: 6310-6315
27 Gibbs C, McCurdy S, Leung L, Paborsky L. Identification of the factor VIIa binding site on tissue factor by homologous loop swap and alanine scanning mutagenesis. Biochemistry 1994; 33: 14003-14010
28 Kelley RF, Costas KE, O’Connell MP, Lazarus RA. Analysis of the factor VIIa binding site on human tissue factor: Effects of tissue factor mutations on the kinetics and thermodynamics of binding. Biochemistry 1995; 34: 10383-10392
29 Nicholls A. GRASP: Graphical representation and analysis surface properties. New York: Columbia University; 1992
30 Ferrin TE, Huang CC, Jarvis LE, Langridge R. The MIDAS display system. J Mol Graph 1988; 06: 13-27