The Significance of Subendothelial von Willebrand Factor

Jacob H Rand; Robert W Glanville; Xiao-Xuan Wu; Julia M Ross; Maurizio Zangari; Ronald E Gordon; Elaine Schwartz; Barry J Potter

doi:10.1055/s-0038-1657567

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1997; 78(01): 445-450
DOI: 10.1055/s-0038-1657567

Pathophysiology of von Willebrand factor

Schattauer GmbH Stuttgart

The Significance of Subendothelial von Willebrand Factor

Jacob H Rand

¹Department of Medicine, Mount Sinai School of Medicine, New York, NY

,

Robert W Glanville

⁴Department of Research, Shriners Hospital for Crippled Children, Portland, OR

,

Xiao-Xuan Wu

¹Department of Medicine, Mount Sinai School of Medicine, New York, NY

,

Julia M Ross

⁵Department of Chemical and Biochemical Engineering, University of Maryland, Baltimore, MD

,

Maurizio Zangari

¹Department of Medicine, Mount Sinai School of Medicine, New York, NY

,

Ronald E Gordon

²Department of Pathology, Mount Sinai School of Medicine, New York, NY

,

Elaine Schwartz

³Department of Dermatology, Mount Sinai School of Medicine, New York, NY

,

Barry J Potter

⁶Alcohol Research Center, Department of Physiology, Louisiana State University Medical Center, New Orleans, LA, USA

› Author Affiliations

Abstract

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References

References
1 Sporn LA, Marder VJ, Wagner DD. Differing polarity of theconstitutive and regulated secretory pathway for von Willebrand fetor in endothelial cells. J Cell Biol 1989; 108: 1283-1289
2 Sussman II, Rand JH. Subendothelial deposition of von Willebrand’s factor requires the presence of endothelial cells. J Lab Clin Med 1982; 100: 526-532
3 Rand JH, Sussman II, Gordon RE, Chu SV, Solomon V. Localization of factor VIII-related antigen in human vascular subendothelium. Blood 1980; 55: 752-756
4 Rand JH, Gordon RE, Sussman II, Chu SV, Solomon V. Electron microscopic localization of factor-VIII-related antigen in adult human blood vessels. Blood 1982; 60: 627-634
5 Sakariassen KS, Bolhuis PA, Sixma JJ. Human blood platelet adhesion to artery subendothelium is mediated by factor VIII-von Willebrand factor bound to the subendothelium. Nature 1979; 279: 636-638
6 Stel HV, Sakariassen KS, de GrootPG, van MourikJA, Sixma JJ. Von Willebrand factor in the vessel wall mediates platelet adherence. Blood 1985; 65: 85-90
7 Turitto VT, Weiss HJ, Zimmerman TS, Sussman II. Factor VIII/ von Willebrand factor in subendothelium mediates platelet adhesion. Blood 1985; 65: 823-831
8 Rand JH, Wu XX, Uson RR, Potter BJ, Gordon RE. Co-localization of von Willebrand factor and type VI collagen in human vascular subendothelium. Am J Pathol 1993; 142: 843-850
9 Wu X-X, Gordon RE, Glanville RW, Kuo H-J, Uson RR, Rand JH. Morphological relationships of von Willebrand factor, type VI collagen and fibrillin in human vascular subendothelium. Am J Pathol 1996; 149: 283-291
10 Wagner DD, Urban PickeringM, Marder VJ. Von Willebrand protein binds to extracellular matrices independently of collagen. Proc Natl Acad Sci U S A 1984; 81: 471-475
11 Rand JH, Patel ND, Schwartz E, Zhou SL, Potter BJ. 150-kD von Willebrand factor binding protein extracted from human vascular subendothelium is type VI collagen. J Clin Invest 1991; 88: 253-259
12 Denis C, Baruch D, Kielty CM, Ajzenberg N, Christophe O, Meyer D. Localization of von Willebrand factor binding domains to endothelial extracellular matrix and to type-VI collagen. Arterioscler Thromb 1993; 13: 398-406
13 Legrand YJ, Fauvel LafeveF. Molecular mechanism of the interaction of subendothelial microfibrils with blood platelets. Nouv Rev Fr Hematol 1992; 34: 17-25
14 Fauvel LafeveF, Arbeille B, de-Romeuf C, Lemesle M, Legrand YJ. Heterogeneity of microfibrils: role of thrombospondin-microfibrils in the thrombogenicity of the subendothelium. C R Acad Sci III 1996; 319: 333-341
15 Rand JH, Badimon L, Gordon RE, Uson RR, Fuster V. Distribution of von Willebrand factor in porcine intima varies with blood vessel type and location. Arteriosclerosis 1987; 07: 287-291
16 Bahnak BR, Wu QY, Coulombel L. et al. Expression of von willebrand factor in porcine vessels: heterogeneity at the level of von Willebrand factor mRNA. Journal of Cellular Physiology 1989; 138: 305-310
17 van derPlas RM, Schiphorst ME, van ZantenGH, Huizinga EG, Vink T, Sixma JJ. Binding of von Willebrand factor to the extracellular matrix and collagen type VI is not mediated by the Al, A2, A3 or D4 domain and is inhibited by MoAb CLB RAg 40. Thromb Haemost. 1997 (in press)
18 Zangari M, Kaplan KL, Glanville RW, Rand JH. Reduced thrombogenicity of type VI collagen as compared to type I collagen. Thromb Res 1995; 79: 429-436
19 Ross JM, Mclntire LV, Moake JL, Rand JH. Platelet adhesion and aggregation on human type VI collagen surface under physiological flow conditions. Blood 1995; 85: 1826-1835
20 Alevriadou BR, Moake JL, Turner NA. et al. Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets. Blood 1993; 81: 1263-1276
21 Chu ML, Pan TC, Conway D. et al, The structure of type VI collagen. Ann N Y Acad Sci 1990; 580: 55-63
22 Cruz MA, Yuan HB, Lee JR, Wise RJ, Handin RL. Interaction of the von Willebrand factor (vWF) with collagen. Localization of the primary collagen-binding site by analysis of recombinant vWF A domain polypeptides. J Biol Chem 1995; 270: 10822-10827
23 Mayer U, Poschl E, Nischt R. et al. Recombinant expression and properties of the Kunitz-type protease-inhibitor module from human type VI collagen alpha 3(VI) chain. Eur J Biochem 1994; 225: 573-580
24 Kuo HJ, Keene DR, Glanville RW. The macromolecular structure of type-VI collagen - Formation and stability of filaments. Eur J Biochem 1995; 232: 364-372
25 Kielty CM, Shuttleworth CA. Fibrillin-containing microfibrils: structure and function in. Int J Biochem Cell Biol 1995; 27: 747-760
26 Keene DR, Maddox BK, Kuo HJ, Sakai LY, Glanville RW. Extraction of extendable beaded structures and their identification as fibrillin-containing extracellular matrix microfibrils. J Histochem Cytochem 1991; 39: 441-449
27 Maslen CL, Glanville RW. The molecular basis of Marfan syndrome. DNA Cell Biol 1993; 12: 561-572
28 Zhang H, Apfelroth SD, Hu W, Davis EC, Sanguineti C, Bonadio J. Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices. J Cell Biol 1994; 124: 855-863
29 Mariencheck MC, Davis EC, Zhang H, Ramirez F, Rosenbloom J, Gibson MA. Fibrillin-1 and fibrillin-2 show temporal and tissue-specific regulation of expression in developing elastic tissue. Connect Tiss Res 1995; 31: 87-97
30 Gibson MA, Sandberg LB, Grosso LE, Cleary EG. Complementary DNA cloning establishes microfibril-associated glycoprotein (MAGP) to be a discrete component of the elastin-as- sociated microfibrils. J Biol Chem 1991; 266: 7596-7601
31 Gibson MA, Hatzinikolas G, Kumaratilake JS, Sandberg LB, Nich oll. Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25). J Biol Chem 1996; 271: 1096-1103
32 Colombatti A, Poletti A, Bressan GM, Carbone A, Volpin D. Widespread codistribution of glycoprotein gp 115 and elastin in chick eye and other tissues. Coll Relat Res 1987; 07: 259-275
33 Kobayashi R, Tashima Y, Masuda H. et al. Isolation and characterization of a new 36-kDa microfibril-associated glycoprotein from porcine aorta. J Biol Chem 1989; 264: 17437-17444
34 Gibson MA, Hatzinikolas G, Davis EC, Baker E, Sutherland GR. Bovine latent transforming growth factor beta 1-binding protein. Mol Cell Biol 1995; 15: 6932-6942
35 Dallas SL, Miyazono K, Skerry TM, Mundy GR, Bonewald LF. Dual role for the latent transforming growth factor-beta binding. J Cell Biol 1995; 131: 539-549
36 Horrigan SK, Rich CB, Streeten BW, Li ZY, Foster JA. Characterization of an associated microfibril protein through recombinant DNA techniques. J Biol Chem 1992; 267: 10087-10095
37 Abrams WR, Ma RI, Kucich U, Bashir MM, Decker S, Tsipouras P. Molecular cloning of the microfibrillar protein MFAP3 and assignment of the gene to human chromosome 5q32-q33.2. Genomics 1995; 26: 47-54
38 Zhao Z, Lee CC, Jiralerspong S, Juyal RC, Lu F, Baldini A. The gene for a human microfibril-associated glycoprotein is commonly deleted in Smith-Magenis syndrome patients. Hum Mol Genet 1995; 04: 589-597
39 Gibson MA, Kumaratilake JS, Cleary EG. The protein components of the 12-nanometer microfibrils of elastic and nonelastic tissues. J Biol Chem 1989; 264: 4590-4598
40 Mazzucato M, Masotti A, Perris R. et al. Effect of different shear forces on vWF-mediated platelet adhesion and aggregation on collagen type VI. Blood 1996; 88: 29a