Download PDF
Thromb Haemost 1997; 78(01): 636-640
DOI: 10.1055/s-0038-1657603
Epidemiology of inherited thrombophilia
Schattauer GmbH Stuttgart

The Epidemiology of lnherited Thrombophilia: the VITA Project

Francesco Rodeghiero
Hemophilia and Thrombosis Center, Department of Hematology, S. Bortolo Hospital, Vicenza, Italy
,
Alberto Tosetto
Hemophilia and Thrombosis Center, Department of Hematology, S. Bortolo Hospital, Vicenza, Italy
› Author Affiliations
Further Information

Publication History

Publication Date:
30 July 2018 (online)

Also available at
  PDF Download  Permissions and Reprints
 

  • References

  • 1 Mannucci PM, Tripodi A. Laboratory screening of inherited thrombotic syndromes. Thromb Haemost 1987; 57: 247-251
    Article in Thieme ConnectPubMedGoogle Scholar
  • 2 Miletich J, Sherman L, Broze Jr G. Absence of thrombosis in subjects with heterozygous protein C deficiency. N Engl J Med 1987; 317: 991-996
    CrossrefPubMedGoogle Scholar
  • 3 Tait RC, Walker ID, Perry DJ, Islam SIAM, Daly ME, McCall F, Conkie JA, Carrell RW. Prevalence of antithrombin deficiency in the healthy population. Br J Haematol 1994; 87: 106-112
    CrossrefPubMedGoogle Scholar
  • 4 Tait RC, Walker ID, Reitsma PH, Islam SIAM, McCall F, Poort SR, Conkie JA, Bertina RM. Prevalence of protein C deficiency in the healthy population. Thromb Haemost 1995; 73: 87-93
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 Briet E, Engesser L, Brommer EJ, Broekmans AW, Bertina RM. Thrombophilia: its causes and a rough estimate of its prevalence. Thromb Haemost 1987; 58: 39
    PubMedGoogle Scholar
  • 6 Finazzi G, Barbui T. Different incidence of venous thrombosis in patients with inherited deficiencies of anti thrombin III protein C and protein. Thromb Haemost 1994; 71: 15-18
    Article in Thieme ConnectPubMedGoogle Scholar
  • 7 Demers C, Ginsberg JS, Hirsh J, Henderson P, Blajchman MA. Thrombosis in antithrombin-III-deficient persons. Report of a large kindred and literature review. Ann Intern Med 1992; 116: 754-761
    CrossrefPubMedGoogle Scholar
  • 8 Allaart CF, Poort SR, Rosendaal FR, Reitsma PH, Bertina RM, Briet E. Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect. Lancet 1993; 341: 134-138
    CrossrefPubMedGoogle Scholar
  • 9 Zoller B, Berntsdotter A, Garcia de Frutos P, Dahlback B. Resistance to activated protein C as an additional risk factor in hereditary deficiency of protein S. Blood 1995; 85: 3518-3523
    PubMedGoogle Scholar
  • 10 Zoller B, Svensson PJ, He X, Dahlback B. Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C. J Clin Invest 1994; 94: 2521-2524
    CrossrefPubMedGoogle Scholar
  • 11 Koeleman BP, Reitsma PH, Allaart CF, Bertina RM. Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families. Blood 1994; 84: 1031-1035
    PubMedGoogle Scholar
  • 12 Mandel H, Brenner B, Berant M, Rosenberg N, Lanir N, Jakobs C, Fowler B, Seligsohn U. Coexistence of hereditary homocystinuria and Factor V Leiden – Effect on thrombosis. N Engl J Med 1996; 334: 763-768
    CrossrefPubMedGoogle Scholar
  • 13 Svensson PJ, Dahlback B. Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med 1994; 330: 521-522
    PubMedGoogle Scholar
  • 14 Rodeghiero F, Tosetto A. Some remarks on the epidemiology of thrombotic disorders. Thromb Haemost 1993; 69: 527-528
    Article in Thieme ConnectPubMedGoogle Scholar
  • 15 Heijboer H, Brandjes DP, Buller HR, Sturk A, ten Cate JW. Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep-vein thrombosis. N Engl J Med 1990; 323: 1512-1516
    CrossrefPubMedGoogle Scholar
  • 16 Ben-Tal O, Zivelin A, Seligsohn U. The relative frequency of hereditary thrombotic disorders among 107 patients with thrombophilia in Israel. Thromb Haemost 1989; 61: 50-54
    Article in Thieme ConnectPubMedGoogle Scholar
  • 17 Gladson CL, Scharrer I, Hach V, Beck KH, Griffin JH. The frequency of type I heterozygous protein S and protein C deficiency in 141 unrelated young patients with venous thrombosis. Thromb Haemost 1988; 59: 18-22
    Article in Thieme ConnectPubMedGoogle Scholar
  • 18 Pabinger I, Brucker S, Kyrle PA, Schneider B, Korninger HC, Niessner H, Lechner K. Hereditary deficiency of antithrombin protein C and protein S: prevalence in patients with a history of venous thrombosis and criteria for rational patient screening. Blood Coagul Fibrinolysis 1992; 03: 547-553
    CrossrefPubMedGoogle Scholar
  • 19 Vikydal R, Korninger C, Kyrle PA, Niessner H, Pabinger I, Thaler E, Lechner K. The prevalence of hereditary antithrombin-III deficiency in patients with a history of venous thromboembolism. Thromb Haemost 1985; 54: 744-745
    Article in Thieme ConnectPubMedGoogle Scholar
  • 20 Rodeghiero F, Tosetto A. The VITA Project: Population-based distribution of Protein C Antithrombin III Heparin Cofactor II and plasminogen. Relationship with physiological variables and establishment of reference ranges. Thromb Haemost 1996; 76: 226-233
    Article in Thieme ConnectPubMedGoogle Scholar
  • 21 Frezzato M, Tosetto A, Rodeghiero F. Validated questionnaire for the identification of previous personal or familial venous thromboembolism. Am J Epidemiol 1996; 143: 1257-1265
    CrossrefPubMedGoogle Scholar
  • 22 Rose GA. The diagnosis of ischemic heart pain and intermittent claudication in field surveys. Bull WHO 1962; 27: 645-658
    PubMedGoogle Scholar
  • 23 The ARIC Investigators. The Atherosclerosis Risk In Communities (ARIC) study: design and objectives. Am J Epidemiol 1989; 129: 687-702
    CrossrefPubMedGoogle Scholar
  • 24 Tosetto A, Rodeghiero F. Diagnosis of APC resistance in patients on oral anticoagulant therapy. Thromb Haemost 1995; 73: 732-733
    Article in Thieme ConnectPubMedGoogle Scholar
  • 25 Tosetto A, Missiaglia E, Gatto E, Rodeghiero F. The Vita Project: phenotypic resistance to activated Protein C and FV Leiden mutation in the general population, (submitted).
    PubMedGoogle Scholar
  • 26 Tosetto A, Gatto E, Rodeghiero F. Influence of cholesterol, triglycerides and fibrinogen on AT-III, PC, HC-II and plasminogen measurement. Thromb Haemost 1997 (in press).
    PubMedGoogle Scholar
  • 27 Tosetto A, Gatto E, Masiero MT, Rodeghiero F. Parallel line bioassay or single-point calibration for the establishment of reference ranges. Thromb Res 1994; 75: 479-483
    CrossrefPubMedGoogle Scholar
  • 28 Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-1134
    CrossrefPubMedGoogle Scholar
  • 29 Dahlback B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci U S A 1993; 90: 1004-1008
    CrossrefPubMedGoogle Scholar
  • 30 Briet E, van der Meer FJ, Rosendaal FR, Houwing Duistermaat JJ, van Houwelingen HC. The family history and inherited thrombophilia. Br J Haematol 1994; 87: 348-352
    CrossrefPubMedGoogle Scholar
  • 31 Tosetto A, Frezzato M, Rodeghiero F. Family history and inherited thrombophilia. Br J Haematol 1995; 89: 227-228
    CrossrefPubMedGoogle Scholar
  • 32 Tosetto A, Missiaglia E, Frezzato M, Rodeghiero F. The VITA Project: C677T Mutation in the Methylene-TetraHydroFolate Reductase Gene and Risk of Venous Thromboembolism, (submitted).
    PubMedGoogle Scholar
  • 33 De StefanoV, Leone G, Mastrangelo S, Tripodi A, Rodeghiero F, Castaman G, Barbui T, Finazzi G, Bizzi B, Mannucci PM. Clinical manifestations and management of inherited thrombophilia: retrospective analysis and follow-up after diagnosis of 238 patients with congenital deficiency of antithrombin III protein C, protein S. Thromb Haemost 1994; 72: 352-358
    Article in Thieme ConnectPubMedGoogle Scholar