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Thromb Haemost 1997; 78(01): 699-704
DOI: 10.1055/s-0038-1657615
Lessons from gene knock-out technology
Schattauer GmbH Stuttgart

Consequences of Tissue Factor Pathway Inhibitor Gene-Disruption in Mice

Zhong-Fu Huang
Washington University Medical Center Barnes-Jewish Hospital, St. Louis, MO, USA
,
George Broze Jr.
Washington University Medical Center Barnes-Jewish Hospital, St. Louis, MO, USA
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Publication History

Publication Date:
31 August 2018 (online)

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  • References

  • 1 Broze Jr GJ. Tissue factor pathway inhibitor and the revised theory of coagulation. Annu Rev Med 1995; 46: 103-112
    CrossrefPubMedGoogle Scholar
  • 2 Novotny WF, Girard TJ, Miletich JP, Broze Jr GJ. Purification and characterization of the lipoprotein-associated coagulation inhibitor from human plasma. J Biol Chem 1989; 264: 18831-18837
    PubMedGoogle Scholar
  • 3 Novotny WF, Girard TJ, Miletich JP, Broze Jr GJ. Platelets secrete a coagulation inhibitor functionally and antigenically similar to the lipoprotein-associated coagulation inhibitor. Blood 1988; 72: 2020-2025
    CrossrefPubMedGoogle Scholar
  • 4 Sandset PM, Abildgaard U, Larsen ML. Heparin induces release of extrinsic coagulation pathway inhibitor (EPI). Thromb Res 1988; 50: 803-813
    CrossrefPubMedGoogle Scholar
  • 5 Novotny WF, Brown SG, Miletich JP, Rader DJ, Broze Jr GJ. Plasma antigen levels of the lipoprotein-associated coagulation inhibitor in patient samples. Blood 1991; 78: 387-393
    CrossrefPubMedGoogle Scholar
  • 6 Wun TC, Kretzmer KK, Girard TJ, Miletich JP, Broze Jr GJ. Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains. J Biol Chem 1988; 263: 6001-6004
    CrossrefPubMedGoogle Scholar
  • 7 Girard TJ, Warren LA, Novotny WF, Likert KM, Brown SG, Miletich JP, Broze Jr GJ. Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor. Nature 1989; 338: 518-520
    CrossrefPubMedGoogle Scholar
  • 8 Wesselschmidt RI, Likert KM, Huang Z-F, MacPhail L, Broze Jr GJ. Structural requirements for tissue factor pathway inhibitor interactions with factor Xa and heparin. Blood Coag Fibrinol 1993; 04: 661-669
    CrossrefPubMedGoogle Scholar
  • 9 Enjyoji K, Miyata T, Kamikubo Y, Kato H. Effect of heparin on the inhibition of factor Xa by tissue factor pathway inhibitor A segment, Gly212-Phe243, of the third Kunitz domain is a heparin binding site. Biochemistry 1995; 34: 5725-5735
    CrossrefPubMedGoogle Scholar
  • 10 Ho G, Toomey JR, Broze Jr GJ, Schwartz A. Receptor-mediated endocytosis of coagulation factor Xa requires cell surface-bound tissue factor pathway inhibitor. J Biol Chem 1996; 271: 9497-9502
    CrossrefPubMedGoogle Scholar
  • 11 Sevinsky JR, Rao LVM, Ruf W. Ligand-induced protease receptor translocation into caveolae: A mechanism for regulating cell surface proteolysis of the tissue factor-dependent coagulation pathway. J Cell Biol 1996; 133: 293-304
    CrossrefPubMedGoogle Scholar
  • 12 Sandset PM, Wam-Cramer BJ, Rao LVM, Maki SL, Rapaport SI. Depletion of extrinsic pathway inhibitor (EPI) sensitizes rabbits to disseminated intravascular coagulation induced with tissue factor: Evidence supporting a physiologic role for EPI as a natural anticoagulant. Proc Natl Acad Sci USA 1991; 88: 708-712
    CrossrefPubMedGoogle Scholar
  • 13 Sandset PM, Warn-Cramer BJ, Maki SL, Rapaport SI. Immunodepletion of extrinsic pathway inhibitor sensitizes rabbits to endotoxin-induced intravascular coagulation and the generalized Schwartzman reaction. Blood 1991; 78: 1496-1502
    PubMedGoogle Scholar
  • 14 Day KC, Hoffman LC, Palmier MO, Kretzmer KK, Huang MD, Pyla EY, Spokas E, Broze Jr GJ, Warren TG, Wun T-C. Recombinant lipoprotein-associated coagulation inhibitor inhibits tissue thromboplastin-induced intravascular coagulation in the rabbit. Blood 1990; 76: 1538-1545
    PubMedGoogle Scholar
  • 15 Creasey AA, Chang AC, Feigen L, Wun T-C, Taylor Jr FB, Hinshaw LB. 1993.Tissue factor pathway inhibitor reduces mortality from E. coli septic shock. J Clin Invest 1993; 91: 2850-2856
    CrossrefPubMedGoogle Scholar
  • 16 Wam-Cramer BJ, Rapaport SI. Studies of factor Xa/phospholipid induced intravascular coagulation in rabbits. Effects of immunodepletion of tissue factor pathway inhibitor. Arterioscler Thromb 1993; 13: 1551-1557
    CrossrefPubMedGoogle Scholar
  • 17 Huang Z-F, Higuchi D, Lasky N, Broze Jr GJ. Tissue factor pathway inhibitor (TFPI) gene-disruption in mice produces intrauterine hemorrhage and lethality. 1997. Manuscript submitted
    Google Scholar
  • 18 Bugge TH, Xiao Q, Kombrinck KW, Flick MJ, Holmback K, Danton MJS, Colbert MC, Witte DP, Fujikawa K, Davie EN, Degen JL. Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation. Proc. Natl. Acad Sci USA 1996; 93: 6258-6263
    CrossrefPubMedGoogle Scholar
  • 19 Toomey JR, Kratzer KE, Lasky NM, Stanton JJ, Broze Jr GJ. Targeted disruption of the murine tissue factor gene results in embryonic lethality. Blood 1996; 88: 1583-1587
    CrossrefPubMedGoogle Scholar
  • 20 Carmeliet P, Mackman N, Moons L, Luther T, Gressens P, van VlaenderenI, Demunck H, Kasper M, Breier G, Evrard P, Muller M, Risau W, Edgington T, Collen D. Role of tissue factor in embryonic blood vessel development. Nature 1996; 383: 73-75
    CrossrefPubMedGoogle Scholar
  • 21 Luther T, Flossel C, Mackman N, Bierhaus A, Kasper M, Albrecht S, Sage EH, Iruela-Arispe L, Grossman H, Strohlein A, Zhang Y, Nawroth PP, Carmeliet P, Loskutoff KJ, Muller M. Tissue factor expression during human and mouse development. Amer.J. Pathol 1996; 149: 101-113
    PubMedGoogle Scholar
  • 22 Hassan HJ, Leonardi A, Chelucci C, Mattia G, Macioce G, Guerriero R, Russo G, Mannucci PM, Peschle C. Blood coagulation factors in human embryonic-fetal development: Preferential expression of FVII/tissue factor pathway. Blood 1990; 76: 1158-1164
    PubMedGoogle Scholar
  • 23 Suh TT, Holmback K, Jensen NJ, Daugherty CC, Small K, Simon DI, Potter S, Degen JL. Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. Genes & Development. 1995; 09: 2020-2033
    CrossrefPubMedGoogle Scholar
  • 24 Bi L, Lawler AM, Antonarakis SE, High KA, Gearhart JD, Kazazian Jr HH. Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A. Nature Genetics 1995; 10: 119-121
    CrossrefPubMedGoogle Scholar
  • 25 Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocytes development. Cell 1995; 81: 695-704
    CrossrefPubMedGoogle Scholar
  • 26 Cui J, O’Sheat KS, Purkayastha A, Saunders TL, Ginsburg D. Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V. Nature 1996; 384: 66-68
    CrossrefPubMedGoogle Scholar