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Thromb Haemost 1997; 78(01): 747-754
DOI: 10.1055/s-0038-1657623
Tissue factor
Schattauer GmbH Stuttgart

Regulation of the Tissue Factor Gene

Nigel Mackman
The Scripps Research Institute, La Jolla, CA, USA
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Publication Date:
12 July 2018 (online)

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  • References

  • 1 Abate C, Curran T. Encounters with Fos and Jun on the road to AP-1. Semin Cancer Biol 1990; 01: 19-26
    PubMedGoogle Scholar
  • 2 Abate C, Luk D, Gagne E, Roeder RG, Curran T. Fos and jun cooperate in transcriptional regulation via heterologous activation domains. Mol Cell Biol 1990; 10: 5532-5535
    CrossrefPubMedGoogle Scholar
  • 3 Beg AA, Baldwin Jr AS. The IκB proteins: multifunctional regulators of Rel/NF-κB transcription factors. Genes Dev 1993; 07: 2064-2070
    CrossrefPubMedGoogle Scholar
  • 4 Berg JM. Spl and the subfamily of zinc finger proteins with guanine-rich binding sites. Proc Natl Acad Sci USA 1992; 89: 11109-11110
    CrossrefPubMedGoogle Scholar
  • 5 Bierhaus A, Zhang Y, Deng Y. et al. Mechanism of the tumor necrosis factor α-mediated induction of endothelial tissue factor. J Biol Chem 1995; 270: 26419-26432
    CrossrefPubMedGoogle Scholar
  • 6 Bierhaus A, Hemmer CJ, Mackman N. et al. Antiparasitic treatment of patients with P. falciparum malaria reduces the ability of patient serum to induce tissue factor by decreasing NF-κB activation. Thromb Haemost 1995; 73: 39-48
    Article in Thieme ConnectPubMedGoogle Scholar
  • 7 Brand K, Fowler BJ, Edgington TS, Mackman N. Tissue factor mRNA in THP-1 monocytic cells is regulated at both transcriptional and posttranscriptional levels in response to lipopolysaccharide. Mol Cell Biol 1991; 11: 4732-4738
    CrossrefPubMedGoogle Scholar
  • 8 Cao X, Koski RA, Gashler A. et al. Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals. Mol Cell Biol 1990; 10: 1931-1939
    CrossrefPubMedGoogle Scholar
  • 9 Coleman DL, Bartiss AH, Sukhatme VP, Liu J, Rupprecht HD. Lipopolysaccharide induces Egr-1 mRNA and protein in murine peritoneal macrophages. J Immunol 1992; 149: 3045-3051
    PubMedGoogle Scholar
  • 10 Contrino J, Hair G, Kreutzer DL, Rickies FR. In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. Nature Med 1996; 02: 209-215
    CrossrefPubMedGoogle Scholar
  • 11 Cui M-Z, Parry GCN, Edgington TS, Mackman N. Regulation of tissue factor gene expression in epithelial cells. Induction by serum and phorbol 12-myristate 13-acetate. Arterioscler Thromb 1994; 14: 807-814
    CrossrefPubMedGoogle Scholar
  • 12 Cui M-Z, Parry GCN, Oeth P. et al. Transcriptional regulation of the tissue factor gene in human epithelial cells is mediated by Sp1 and EGR-1. J Biol Chem 1996; 271: 2731-2739
    CrossrefPubMedGoogle Scholar
  • 13 Dokter WHA, Esselink MT, Halie MR, Vellenga E. Interleukin-4 inhibits the lipopolysaccharide-induced expression of c-jun and c-fos messenger RNA and activator protein-1 binding activity in human monocytes. Blood 1993; 81: 337-343
    PubMedGoogle Scholar
  • 14 Donovan-Peluso M, George LD, Hassett AC. Lipopolysaccharide induction of tissue factor expression in THP-1 monocytic cells. J Biol Chem 1994; 269: 1361-1369
    PubMedGoogle Scholar
  • 15 Drake TA, Cheng J, Chang A, Taylor Jr. FB. Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal Escherichia coli sepsis. Am J Pathol 1993; 142: 01-13
    PubMedGoogle Scholar
  • 16 Fan S-T, Mackman N, Cui M-Z, Edgington TS. Integrin regulation of an inflammatory effector gene: Direct induction of the tissue factor promoter by engagement of β1 or α4 integrin chains. J Immunol 1995; 154: 3266-3274
    PubMedGoogle Scholar
  • 17 Felts SJ, Stoflet ES, Eggers CT, Getz MJ. Tissue factor gene transcription in serum-stimulated fibroblasts is mediated by recruitment of c-Fos into specific AP-1 DNA-binding complexes. Biochemistry 1995; 34: 12355-12362
    CrossrefPubMedGoogle Scholar
  • 18 Gonzalez-Dunia D, Eddleston M, Mackman N, Carbone K, de la Torre JC. Expression of tissue factor is increased in astrocytes within the central nervous sytem during persistent infection with boma disease virus. J Virol 1996; 70: 5812-5820
    PubMedGoogle Scholar
  • 19 Gregory SA, Morrissey JH, Edgington TS. Regulation of tissue factor gene expression in the monocyte procoagulant response to endotoxin. Mol Cell Biol 1989; 9: 2752-2755
    CrossrefPubMedGoogle Scholar
  • 20 Grilli M, Chiu JJ-S, Lenardo MJ. NF-κB and Rel: Participants in a multiform transcriptional regulatory system. In: Jeon KW, Friedlander M, Jarvik J. (eds). International Review of Cytology. 143th ed. San Diego, CA: Academic Press; 1993: 01-62
    Google Scholar
  • 21 Groupp ER, Donovan-Peluso M. Lipopolysaccharide induction of THP-1 cells activates binding of c-Jun, Ets, and Egr-1 to the tissue factor promoter. J Biol Chem 1996; 271: 12423-12430
    CrossrefPubMedGoogle Scholar
  • 22 Hambleton J, Weinstein SL, Lem L, DeFranco AL. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci USA 1996; 93: 2774-2778
    CrossrefPubMedGoogle Scholar
  • 23 Hartzell S, Ryder K, Lanahan A, Lau LF, Nathans D. A growth factor-responsive gene of murine BALB/c 3T3 cells encodes a protein homologous to human tissue factor. Mol Cell Biol 1989; 9: 2567-2573
    CrossrefPubMedGoogle Scholar
  • 24 Hölschermann H, Dürfeld F, Maus U. et al. Cyclosporine A inhibits tissue factor expression in monocytes/macrophages. Blood 1996; 88: 3837-3845
    CrossrefPubMedGoogle Scholar
  • 25 Kadonaga JT, Jones KA, Tjian R. Promoter-specific activation of RNA polymerase II transcription. TIBS 1986; 11: 20-23
    PubMedGoogle Scholar
  • 26 Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 1995; 270 (28) 16483-16486
    CrossrefPubMedGoogle Scholar
  • 27 Kirchhofer D, Tschopp TB, Hadvary P, Baumgartner HR. Endothelial cells stimulated with tumor necrosis factor-α express varying amounts of tissue factor resulting in inhomogenous fibrin deposition in a native blood flow system. J Clin Invest 1994; 93: 2073-2083
    CrossrefPubMedGoogle Scholar
  • 28 LeMaire P, Vesque C, Schmitt J, Stunnenberg H, Frank R, Chamay P. The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activator. Mol Cell Biol 1990; 10: 3456-3467
    CrossrefPubMedGoogle Scholar
  • 29 Lin M-C, Shyy JY-J, Almus-Jacobs F. et al. The shear stress-induced tissue factor gene expression is mediated through the Sp1 Cis-element. Proc Natl Acad Sci USA. 1997 in press
    PubMedGoogle Scholar
  • 30 Mackman N. Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers. J Biol Chem 1994; 269: 26363-26367
    CrossrefPubMedGoogle Scholar
  • 31 Mackman N. Regulation of the tissue factor gene. FASEB J 1995; 09: 883-889
    CrossrefPubMedGoogle Scholar
  • 32 Mackman N, Brand K, Edgington TS. Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor κB binding sites. J Exp Med 1991; 174: 1517-1526
    CrossrefPubMedGoogle Scholar
  • 33 Mackman N, Fowler BJ, Edgington TS, Morrissey JH. Functional analysis of the human tissue factor promoter and induction by serum. Proc Natl Acad Sci USA 1990; 87: 2254-2258
    CrossrefPubMedGoogle Scholar
  • 34 Mackman N, Imes S, Maske WH, Taylor B, Lusis AJ, Drake TA. Structure of the murine tissue factor gene: Chromosome location and conservation of regulatory elements in the promoter. Arterioscler Thromb 1992; 12 (04) 474-483
    CrossrefPubMedGoogle Scholar
  • 35 Mackman N, Morrissey JH, Fowler B, Edgington TS. Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade. Biochemistry 1989; 28: 1755-1762
    CrossrefPubMedGoogle Scholar
  • 36 Moll T, Czyz M, Holzmuller H. et al. Regulation of the tissue factor promoter in endothelial cells. J Biol Chem 1995; 270: 3849-3857
    CrossrefPubMedGoogle Scholar
  • 37 Müller JM, Ziegler-Heitbrock HWL, Baeuerle PA. Nuclear factor kappa B, a mediator of lipopolysaccharide effects. Immunobiol 1993; 187: 233-256
    CrossrefPubMedGoogle Scholar
  • 38 Oeth P, Mackman N. Salicylates inhibit lipopolysaccharide induced transcriptional activation of the human tissue factor gene in monocytic cells. Blood 1995; 86: 4144-4152
    PubMedGoogle Scholar
  • 39 Oeth P, Parry GCN, Mackman N. Regulation of the tissue factor gene in human monocytic cells: role of AP-1, NF-κB/Rel and Sp1 proteins in uninduced and lipopolysaccharide induced expression. Arterioscler Thromb Vasc Biol. in press.
    Google Scholar
  • 40 Oeth PA, Parry GCN, Kunsch C, Nantermet P, Rosen CA, Mackman N. Lipopolysaccharide induction of tissue factor gene expression in monocytic cells is mediated by binding of c-Rel/p65 heterodimers to a κB-like site. Mol Cell Biol 1994; 14: 3772-3781
    CrossrefPubMedGoogle Scholar
  • 41 Osnes LTN, Foss KB, Joo GB. et al. Acetylsalicylic acid and sodium salicylate inhibit LPS-induced NF-κB/c-Rel nuclear translocation, and synthesis of tissue factor (TF) and tumor necrosis factor alfa (TNF-α) in human monocytes. Thromb Haemost 1996; 76: 970-976
    Article in Thieme ConnectPubMedGoogle Scholar
  • 42 Pany GCN, Mackman N. A set of inducible genes expressed by activated human monocytic and endothelial cells contain κB-like sites that specifically bind c-Rel-p65 heterodimers. J Biol Chem 1994; 269: 20823-20825
    PubMedGoogle Scholar
  • 43 Parry GCN, Mackman N. Transcriptional regulation of tissue factor expression in human endothelial cells. Arterioscler Thromb 1995; 15: 612-621
    CrossrefPubMedGoogle Scholar
  • 44 Perkins ND, Agranoff AB, Pascal E, Nabel GJ. An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation. Mol Cell Biol 1994; 14: 6570-6583
    CrossrefPubMedGoogle Scholar
  • 45 Perkins ND, Edwards NL, Duckett CS, Agranoff AB, Schmid RM, Nabel GJ. A Cooperative interaction between NF-κB and Sp1 is required for HIV-1 enhancer activation. EMBO J 1993; 12: 3551-3558
    PubMedGoogle Scholar
  • 46 Quirk SM, Pentecost BT, Mackman N, Loskutoff DJ, Hartzell S, Henrikson KP. The regulation of uterine tissue factor by estrogen. Endocrine 1995; 3: 177-184
    CrossrefPubMedGoogle Scholar
  • 47 Ranganathan G, Blatti SP, Subramaniam M, Fass DN, Maihle NJ, Getz MJ. Cloning of murine tissue factor and regulation of gene expression by transforming growth factor type beta1. J Biol Chem 1991; 266: 496-501
    PubMedGoogle Scholar
  • 48 Taby O, Rosenfield C-L, Bogdanov V, Nemerson Y, Taubman MB. Cloning of the rat tissue factor cDNA and promoter: identification of a serum-response region. Thromb Haemost 1996; 76: 697-702
    Article in Thieme ConnectPubMedGoogle Scholar
  • 49 Wrighton CJ, Hofer-Warbinek R, Moll T, Eytner R, Bach FH, de Martin R. Inhibition of endothelial cell activation by adenovirus-mediated expression of IκBα, an inhibitor of the transcription factor NF-κB. J Exp Med 1996; 183: 1013-1022
    CrossrefPubMedGoogle Scholar