Incidence of Arg506 → GIn Mutation (Factor V Leiden) in Pima Indians

Hans P Kohler; May Boothby; Lynn McCormack; William C Knowler; Peter J Grant

doi:10.1055/s-0038-1657662

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1997; 78(02): 961-962
DOI: 10.1055/s-0038-1657662

Letter to the Editor

Schattauer GmbH Stuttgart

Incidence of Arg506 → GIn Mutation (Factor V Leiden) in Pima Indians

Authors

Hans P Kohler

¹The Unit of Molecular Vascular Medicine, Department of Clinical Medicine, University of Leeds, UK
May Boothby

¹The Unit of Molecular Vascular Medicine, Department of Clinical Medicine, University of Leeds, UK
Lynn McCormack

¹The Unit of Molecular Vascular Medicine, Department of Clinical Medicine, University of Leeds, UK
William C Knowler

²The National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA
Peter J Grant

¹The Unit of Molecular Vascular Medicine, Department of Clinical Medicine, University of Leeds, UK

Abstract

PDF Download

PDF (440 kb)

References

References
1 Koster T, Rosendaal FR, de RondeH, Briet E, Vandenbroucke JP, Bertina RM. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet 1993; 342: 1503-1506
2 Dahlback B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90: 1001-1008
3 Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, de RondeH, van derVelden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-67
4 Ridker PM, Hennekens CH, Lindpainter K, Stampfer MJ, Eisenberg PR, Miletich JP. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. N Engl J Med 1995; 332: 912-917
5 Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-1134
6 Pepe G, Rickards o, Vanegas OC, Brunelli T, Gori AM, Giusti B, Attanasio M. et al Prevalence of factor V Leiden mutation in non-European populations. Thromb Haemost 1997; 77: 329-331
7 Nelson RG, Sievers ML, Knowler WC, Swinbum BH, Pettitt DJ, Saad MF, Liebow IM, Howard BV, Bennett PH. Low incidence of fatal coronary heart disease in Pima Indians despite high prevalence of Noninsulin-dependent diabetes. Circulation 1990; 81: 987-995
8 Severs ML, Nelson RG, Bennett PH. Sequential trends in overall and cause specific mortality in diabetic and nondiabetic Pima Indians. Diabetes Care 1996; 19: 107-111
9 Catto A, Carter A, Ireland H, Bayston TA, Philippou H, Barrett J, Lane DA, Grant PJ. Factor V Leiden mutation and thrombin generation in relation to the development of acute stroke. Arteriosclerosis, Thrombosis, and Vascular Biology 1995; 15: 783-785
10 Mansfield M, Stickland M, Carter A, Grant PJ. Polymorphism of the plasminogen activator inhibitor-1 gene in type 1 and type 2 diabetes, and in patients with diabetic retinopathy. Thromb Haemost 1994; 71: 01-03
11 Simioni P, de RondeH, Prandoni P, Saladini M, Bertina RM, Girolami A. Ischemic stroke in young patients with activated protein C resistance. A report of three cases belonging to three different kindreds. Stroke 1995; 26: 885-890
12 Wild S, McKeigue P. Cross sectional analysis of mortality by country of birth in England and Wales, 1970-1992. BMJ 1997; 314: 705-710
13 Arruda VR, von ZubenPM, Soares MCP, Menezes R, Annichino-Bizzacchi JM, Costa FF. Very low incidence of Arg506→Gln mutation in the factor V gene among the Amazonian Indians and the Brazilian black population. Thromb Haemost 1996; 75: 860-861 (letter)
14 Burkitt DP. Varicose veins, deep vein thrombosis, and haemorrhoids: epidemiology and suggested aetiology. BMJ 1972; 02: 556-561