Thromb Haemost 1997; 78(02): 962-963
DOI: 10.1055/s-0038-1657663
Letter to the Editor
Schattauer GmbH Stuttgart

The Prevalence of Factor V Leiden (Gln506) in Polynesians

Neil Van de Water
The Department of Haematology, Auckland Hospital and Department of Molecular Medicine, School of Medicine, University of Auckland, Auckland, New Zealand
,
Ruth Williams
The Department of Haematology, Auckland Hospital and Department of Molecular Medicine, School of Medicine, University of Auckland, Auckland, New Zealand
,
Andrew Dare
The Department of Haematology, Auckland Hospital and Department of Molecular Medicine, School of Medicine, University of Auckland, Auckland, New Zealand
,
William Abbott
The Department of Haematology, Auckland Hospital and Department of Molecular Medicine, School of Medicine, University of Auckland, Auckland, New Zealand
,
Peter Browett
The Department of Haematology, Auckland Hospital and Department of Molecular Medicine, School of Medicine, University of Auckland, Auckland, New Zealand
› Author Affiliations
Further Information

Publication History

Received 26 1997

Accepted 24 March 1997

Publication Date:
12 July 2018 (online)

 
  • References

  • 1 Kalafatis M, Rand MD, Mann KG. The mechanism of inactivation of human factor V and human Va by activated protein C. J Biol Chem 1994; 269: 31869-31880
  • 2 Bertina MR, Koeleman PCB, Koster T, Rosendaal RF, Dirven JR, de Ronde, Van derVelden AP, Reitsma HP. Mutation in blood coagulation factor associated with resistance to activated protein C. Nature 1994; 369: 64-67
  • 3 Dahlbäck B. Inherited thrombophilia: Resistance to activated protein C as a pathogenic factor of venous thromboembolism. Blood 1995; 85: 607-614
  • 4 Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-1134
  • 5 Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH. High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 1995; 85: 1504-1508
  • 6 Koster T, Rosendaal FR, de RondeH, Briet E, Vandenbroucke JP, Bertina RM. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet 1993; 342: 1503-1506
  • 7 Takamiya o, Ishida F, Kodaira H, Kitano K. APC-resistance and Mnl I genotype (Gin 506) of coagulation factor V are rare in Japanese population. Thromb Haemost 1995; 74: 996
  • 8 Diamond JM. Express train to Polynesia. Nature 1988; 336: 307-308
  • 9 Van deWater NS, Ridgway D, Ockelford PA. Restriction fragment length polymorphisms associated with the factor VIII and factor IX genes in Polynesians. J Med Genet 1991; 28: 171-176
  • 10 Zivelin A, Griffin JH, Xu X, Pabinger I, Samama M, Conard J, Brenner B, Eldor A, Seligsohn U. A single genetic origin for the common caucasian factor V mutation predisposing to thrombosis. Blood 1996; 88: 284a