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Thromb Haemost 1997; 78(03): 1093-1096
DOI: 10.1055/s-0038-1657692
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Schattauer GmbH Stuttgart

The Influence of Smoking and of Oral and Transdermal Nicotine on Blood Pressure, and Haematology and Coagulation Indices

Andrew D Blann
1   The Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, The City Hospital, Birmingham
,
Christopher Steele
2   The Practice, Manchester, University Hospital of South Manchester, Didsbury, UK
,
Charles N McCollum
3   The Department of Surgery, University Hospital of South Manchester, Didsbury, UK
› Author Affiliations
Further Information

Publication History

Received 31 1996

Accepted after revision 21 April 1997

Publication Date:
30 July 2018 (online)

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Summary

Nicotine is helpful in stopping smoking but its influence on cardiovascular risk factors is incomplete. Our aim was to determine its effect on blood pressure, routine haematology indices, and coagulation indices relevant to thrombosis. Eighteen subjects were seen whilst smoking (cotinine levels 1119 ± 414 ng/ml), again after stopping smoking but while using nicotine chewing gum and/or skin patches (392 ± 198 ng/ml), and again when not using nicotine (cotinine undetectable). There were no significant changes in blood pressures, platelet count, mean platelet volume, viscosity or anti-thrombin III. However, white blood cell count (p = 0.003), lymphocyte count (p = 0.016), red blood cell count (p = 0.02), haemoglobin (p <0.001), fibrinogen (p <0.001) and von Willebrand factor (p = 0.001) all fell between the first and second samples (when still using nicotine) but not between the second and third samples (when off nicotine). Oral and/or transdermal nicotine does not influence blood pressure or the haematology and coagulation indices we have measured.

 

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