A Multivariate Pattern Recognition Study of Risk-Factors Indicating Postoperative Thromboembolism Despite Low-Dose Heparin in Major Abdominal Surgery

Summary

The object of the present investigation was to identify those who, among high-risk patients, would “break through” low-dose heparin prophylaxis and develop thromboembolism after major abdominal surgery.

Twenty-nine variables (clinical characteristics, pre- and postoperative coagulation and fibrinolytic factors) from 19 patients with and 26 patients without thromboembolism were analyzed by means of a multivariate supervised pattern recognition technique (SIMCA).

We found no statistically significant difference between patients with and without thromboembolism. Thus, in the studied group of high-risk patients it was not possible to identify a predictive index for selection of individual patients liable to develop postoperative thromboembolism despite low-dose heparin prophylaxis in major abdominal surgery.

Keywords

Heparin prophylaxis - Major abdominal surgery - Risk factors - Multivariate analysis

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