Reduced Prostacyclin Survival After Fasting-Induced Elevation of Plasma Free Fatty Acids

S H Goodnight; S B Inkeles; N L Kovach; W E Connor

doi:10.1055/s-0038-1657863

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1985; 54(02): 418-421
DOI: 10.1055/s-0038-1657863

Original Article

Schattauer GmbH Stuttgart

Reduced Prostacyclin Survival After Fasting-Induced Elevation of Plasma Free Fatty Acids

S H Goodnight

The Division of Hematology and Medical Oncology and Section of Nutrition, Department of Medicine, Oregon Health Sciences University, Portland, Oregon, USA

,

S B Inkeles

The Division of Hematology and Medical Oncology and Section of Nutrition, Department of Medicine, Oregon Health Sciences University, Portland, Oregon, USA

,

N L Kovach

The Division of Hematology and Medical Oncology and Section of Nutrition, Department of Medicine, Oregon Health Sciences University, Portland, Oregon, USA

,

W E Connor

The Division of Hematology and Medical Oncology and Section of Nutrition, Department of Medicine, Oregon Health Sciences University, Portland, Oregon, USA

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Abstract

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Summary

The anti-thrombotic effect of prostacyclin (PGI₂) may be determined not only by its synthetic rate but also by its subsequent survival in blood. After its release from the vascular wall, prostacyclin binds to plasma albumin which stabilizes the molecule and prolongs its inhibitory effects on platelets. In vitro studies have shown that free fatty acids compete for the same albumin binding sites and may therefore displace PGI₂ and substantially shorten its survival. To see if this competition could also occur in vivo, we produced a three-fold rise of plasma free fatty acid concentrations in ten normal volunteers by four days of fasting, which led to a significant reduction in prostacyclin survival as measured by a functional assay based on inhibition of ADP-induced platelet aggregation. The shortening of prostacyclin survival was associated with evidence of increased platelet reactivity as measured by the circulating platelet aggregate ratio test. Diseases that produce marked elevations of free fatty acids such as acute myocardial infarction may also lead to shortened PGI₂ survival with potentiation of platelet mediated thrombosis.

Keywords

Free fatty acids - Prostacyclin survival - Fasting

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Referenzen

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