Effect of Ciprofibrate on Platelet Aggregation and Fibrinolysis in Patients with Hypercholesterolaemia

Iain A Simpson; A Ross Lorimer; Isobel D Walker; John F Davidson

doi:10.1055/s-0038-1657868

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1985; 54(02): 442-444
DOI: 10.1055/s-0038-1657868

Original Article

Schattauer GmbH Stuttgart

Effect of Ciprofibrate on Platelet Aggregation and Fibrinolysis in Patients with Hypercholesterolaemia

Iain A Simpson

The University Department of Medical Cardiology and Department of Haematology, Royal Infirmary, Glasgow, UK

,

A Ross Lorimer

The University Department of Medical Cardiology and Department of Haematology, Royal Infirmary, Glasgow, UK

,

Isobel D Walker

The University Department of Medical Cardiology and Department of Haematology, Royal Infirmary, Glasgow, UK

,

John F Davidson

The University Department of Medical Cardiology and Department of Haematology, Royal Infirmary, Glasgow, UK

› Author Affiliations

Abstract

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Summary

The fibrinolytic and platelet effects of Ciprofibrate, a new lipid lowering drug, were studied in 7 patients with hypercholesterolaemia over a 12 week period. A significant reduction in plasma fibrinogen was noted and a lesser increase in fibrinolytic activity. However, no change in platelet aggregation was noted. As expected Ciprofibrate produced a significant hypolipidaemic effect in these patients.

We have described effects of Ciprofibrate which may have potential benefits in this high risk patient group.

Keywords

Ciprofibrate - Hypolipidaemic agent - Fibrinolytic activity - Fibrinogen - Hypercholesterolaemia

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References

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