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Thromb Haemost 1985; 54(02): 450-453
DOI: 10.1055/s-0038-1657870
Original Article
Schattauer GmbH Stuttgart

Effects of Adrenaline Infusion on Platelet Number, Volume and Release Reaction

K Lande
The Department of Medicine and Department of Clinical Physiology, Ullevål Hospital, University of Oslo, Oslo, Norway
,
K Gjesdal
The Department of Medicine and Department of Clinical Physiology, Ullevål Hospital, University of Oslo, Oslo, Norway
,
E Fønstelien
The Department of Medicine and Department of Clinical Physiology, Ullevål Hospital, University of Oslo, Oslo, Norway
,
S E Kjeldsen
The Department of Medicine and Department of Clinical Physiology, Ullevål Hospital, University of Oslo, Oslo, Norway
,
I Eide
The Department of Medicine and Department of Clinical Physiology, Ullevål Hospital, University of Oslo, Oslo, Norway
› Author Affiliations
Further Information

Publication History

Received 13 March 1985

Accepted 08 May 1985

Publication Date:
18 July 2018 (online)

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Summary

At the end of a diagnostic right heart catheterization ten patients received an intravenous infusion of l-adrenaline which gradually increased the arterial plasma adrenaline concentration from resting physiological values to high values as seen during myocardial infarction, pheochromocytoma and hypoglycemia. Blood was sampled from the brachial artery, femoral vein and hepatic vein. During the adrenaline infusion venous beta-thromboglobulin concentrations increased 23% from 61 ± 5 to 80 ± 7 μg/l (mean ± SE), arterial platelet counts 20% from 212 ± 17 to 253 ± 25 × 109/l and arterial platelet volume 4% from 7.25 ± 0.20 to 7.56 ± 0.21 femtoliter. All changes were significant at the 5% level. Thus, acute increments of arterial plasma adrenaline significantly stimulated the blood platelet parameters studied.

Keywords

Beta-thromboglobulin - Catecholamines - Platelet function - Thrombosis
 

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